本发明涉及地中海贫血症筛查诊断
技术领域：
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背景技术：
：地中海贫血又称海洋性贫血，多见于地中海、东南亚等地，是一组对人类健康具有严重威胁的致死、致残的遗传性血液病；在1925年由意大利Cooley医生和Lee医生首次报道；有数据表明，我国重型和中间型地贫患者在30万人左右，“地贫”基因携带者超过3000万人，涉及近3000万家庭1亿人口，主要集中在长江以南的云南、四川、海南、贵州、福建、广西、广东等市、省份或自治区，尤以两广地区最为严重，广东“地贫”基因携带者超过10％，广西“地贫”基因携带者超过20％，由于基因携带率高和人口基数大，预防地中海贫血症已经成为我国南方人口出生缺陷的公共卫生战略需求。地中海贫血症的病因是由于血红球蛋白基因缺陷而导致血红蛋白中的一种或几种血红球蛋白肽链的合成减少或者不能合成，导致血红球蛋白的组成成分或者比例发生改变。血红球蛋白由两类亚基组成，一类是α亚基，一类是β亚基；α类亚基簇位于16号染色体，簇的顺序为5'-zeta(ζ)-pseudozeta–mu(μ)-pseudoalpha-1-alpha-2-alpha-1-theta-3'，其中α1和α2的编码序列完全相同，不同的是5’UTR区、3’UTR区和部分内含子区域；β类亚基簇位于11号染色体，簇的顺序为5'–epsilon(ε)–gamma-G–gamma-A–delta(δ)–beta(β)-3'，如图1所示。组成血红球蛋白的肽链有4种，分别是α、β、γ和δ链，这些肽链由相应的基因编码，这些基因的缺失或者点突变可造成不同的肽链的合成障碍，致使血红蛋白的组分改变，因此通常地中海贫血可以分为α、β、δβ和δ等四种类型，其中又以β和α地中海贫血较为常见。α地中海贫血简称α地贫，α血红球蛋白基因簇位于16p13.3，每条染色体上各有2个α血红球蛋白基因，一对染色体共有4个α血红球蛋白；大多数α地贫是由于α血红球蛋白基因的缺失照成的，少数是由基因点突变造成的。β地中海贫血简称β地贫，其基因簇位于11p15.5，β地贫的发生主要是由于基因的点突变，少数为基因缺失，迄今为止全世界已经发现的点突变有1000种以上，根据公开的资料，如图2是地贫点突变的统计数据，可以看到β亚基上的突变占到50％以上。各国的突变热点也有所不同，下面列举了中国、日本、俄罗斯和韩国的β亚基的突变热点和突变频率的数据：其中，中国的β亚基的突变热点和突变频率统计如图3所示。其中，日本的β亚基的突变热点和突变频率统计如图4所示。其中，俄罗斯的β亚基的突变热点和突变频率统计如图5所示。其中，韩国的β亚基的突变热点和突变频率突变频率统计如图6所示。可以看到，各国的主要突变热点和频率不尽相同，例如，韩国的CD41/42(-TTCTor-CTTT)热点的频率是5.6％，而中国该位点的频率是42.3％，对于CD89/90–GT热点而言，韩国的频率是38.9％，而中国却没有统计到该位点，但实际上，中韩两国在漫长的历史中，并不是严格的地域隔绝，中国的朝鲜族与韩国有着共同的血缘背景，因此可见，由于统计范围的关系，这些公开的数据并不能准确的反应国内β亚基突变位点的情况，国内以β亚基热点作为检测对象的试剂盒并不能适用于所有情况，可想而知，将会有较大比例的假阴性的情况出现；并且，国内市面上的检测地中海贫血症的检测试剂盒是将β亚基和α亚基分开检测，并且技术平台也不一样，例如，检测β亚基点突变的是qPCR方法，检测α亚基基因缺失的是gap-PCR或者MLPA(multiplexligation-dependentprobeamplification)，本发明的主要优势在于：1)可同时检测α基因簇和β基因簇上99％的已知点突变，数量约在3000个以上；2)除了可以检测点突变这种类型之外，还可以检测小片段的插入、小片段和大片段的缺失以及拷贝数变化等多种类型；3)在检测已知类型的突变、插入、缺失、拷贝数变化的同时，还能识别未知的新发的基因变异；4)与传统方法比较，有较大的成本优势；技术实现要素：本发明提供一种基于二代高通量测序技术的地中海贫血症的基因检测试剂盒，可以减少目前检测方法的假阴性率，提高检出率，可以实现自动化，使地中海贫血症的筛查诊断更加全面和准确。本发明所采取的技术方案是：一种基于二代高通量测序技术的地中海贫血症的基因检测试剂盒，其中包括：1)基因组DNA提取试剂；2)含有外切酶的片段化试剂；3)片段修复与连接试剂；4)PCR扩增试剂；5)PCR产物纯化试剂；6)捕获探针及其杂交捕获试剂；7)杂交洗脱试剂；8)阴性质控样本；9)阳性质控样本；其中捕获探针所捕获的范围如下所述，其核苷酸序列见序列表：1)hg19，chr16:189,137-232,194；2)hg19，chr11：5,237,140-5,318,776；3)KLF1基因的全部外显子区域以及5’UTR和3’UTR区域；4)以及156个SNP位点本发明还提供了地中海贫血症的基因检测试剂盒在遗传病筛查和诊断中的应用，包括下述步骤：1)用权利要求1所述的1)基因组DNA提取试剂从受测试者唾液或者血液中提取基因组DNA；2)用权利要求1所述的2)含有外切酶的片段化试剂将基因组DNA进行片段化处理；3)用权利要求1所述的3)片段修复与连接试剂将DNA片段的末端进行修复；4)用权利要求1所述的3)片段修复与连接试剂将修复后的DNA片段与人工接头进行连接；5)用权利要求1所述的4)PCR扩增试剂以连接后的DNA片段作为模板进行PCR扩增；6)用权利要求1所述的5)PCR产物纯化试剂对PCR产物进行纯化；7)用权利要求1所述的6)捕获探针机器杂交捕获试剂与PCR产物进行杂交；8)用权利要求1所述的7)杂交洗脱试剂对杂交后的PCR产物进行纯化和洗脱；9)用权利要求1所述的4)PCR扩增试剂以洗脱后的PCR产物作为模板进行PCR扩增；10)用权利要求1所述的5)PCR产物纯化试剂对PCR产物进行纯化；11)对纯化后的PCR产物进行二代高通量测序；12)对测序结果进行分析获得受测试者的地中海贫血症相关基因的信息；附图说明图1是α类亚基簇和β类亚基簇。图2是地贫点突变的统计数据图。图3是中国的β亚基的突变热点和突变频率统计图。图4是日本的β亚基的突变热点和突变频率统计图。图5是俄罗斯的β亚基的突变热点和突变频率统计图。图6是韩国的β亚基的突变热点和突变频率突变频率统计图。图7是典型的DNA提取结果。图8是Swift文库(E1～E7，E15～E21)和VAHTS文库结果图(E8～E14，E22～E28)。具体实施方式本发明一种基于二代高通量测序技术的地中海贫血症的基因检测试剂盒及其在遗传病筛查中的应用，属于地中海贫血症基因诊断
技术领域：
，是一种靶向性测序技术，包括：1)基因组DNA提取试剂；2)含有外切酶的片段化试剂；3)PCR产物纯化试剂；4)片段修复与连接试剂；5)捕获探针及其杂交捕获试剂；6)杂交洗脱试剂；7)PCR扩增试剂；其应用包括以下步骤：1)从受测试者唾液或者血液中提取基因组DNA；2)用外切酶将基因组DNA进行片段化处理；3)用生物酶将DNA片段的末端进行修复；4)用连接酶将修复后的DNA片段与人工接头进行连接；5)以连接后的DNA片段作为模板进行PCR扩增；6)对PCR产物进行纯化；7)用捕获探针与PCR产物进行杂交；8)对杂交后的DNA片段进行纯化和洗脱；9)以洗脱后的DNA片段作为模板进行PCR扩增；10)对PCR产物进行纯化；11)对纯化后的PCR产物进行二代高通量测序；12)对测序结果进行分析获得受测试者的地中海贫血症相关基因的信息。本发明的试剂盒以及操作步骤能适用于现有的自动化工作平台，提高反应通量，缩短筛查诊断时间，使地中海贫血症的基因检测更为快捷可靠。本发明选择HBA家族所在基因簇和HBB家族所在基因簇作为检测对象，囊括了更多目前技术方法无法顾及的检测位点，可直接对受测试者的突变携带进行确诊，显著降低突变的漏诊率，测试的准确性和全面性超过其他常规测试方法。本发明填补了地中海贫血症的二代高通量测序诊断
技术领域：
的空白，极大提高了地中海贫血症的基因缺陷的检出率，对降低病患儿的出生率、提高我国人口素质、减轻我国医疗保健体系的负担等方面具有重要意义。实施例11.样本DNA提取我们比较了两款商品化的外周血DNA提取试剂盒，分别是天根生物DP304TIANampGenomicDNAKit和Qiagen56504QIAampDNAInvestigatorKit，按照厂生产厂家建议的操作流程，最终我们选择了天根生物DP304，典型的DNA提取结果如图7所示。2.实施例方案设计为了证明本方案流程的可靠性，我们用5个样本做了30次不同重复，方案设计如下表，具体而言，我们由两位操作人员，在3个不同的时间节点里分别对相同的5个样本进行重复实验；3.DNA片段化1)二代测序文库要求将样本基因组DNA片段化，在比较了超声和酶切两种方式之后，本发明采用NEB公司的NEBNextdsDNAFragmentase对样本基因组DNA进行片段化处理，并比较了不同酶切时间的片段化效果，最终采用20分钟的酶切时间；具体实施步骤如下：2)在0.2mLPCR管中按比例加入下列组分，总体积10uL，稍微涡旋3sec，无热盖，37℃孵育20分钟；3)加入合适体积的Beads到PCR管中后，稍微涡旋混匀，稍微离心，在室温下放置5分钟；4)在磁力架上放置5分钟；5)在磁力架上，移除管中上清，留下5μL溶液，禁止触动磁珠沉淀；6)在磁力架上，加入160μL新鲜配置的80％乙醇，静置30sec，移除160μL洗涤液；7)重复：在磁力架上，加入160μL新鲜配置的80％乙醇，静置30sec，移除160μL洗涤液；8)低速离心30sec，在磁力架上小心移除余液，置于室温下风干(避免磁珠沉淀开裂)；9)用12μLTE重悬浮磁珠，吹吸5-6次，室温静置1分钟，置于磁力架上5分钟，将11μL上清移入新的PCR管中4℃备用，也可以在-20℃中保存一周；4.文库构建我们选择了Illumina公司的Truseq建库试剂盒、Swift公司的Accel建库试剂盒和VAHTS公司的Nano建库试剂盒，从操作步骤、试剂价格、建库效果等多个方面进行比较，最终确认VAHTS公司的Nano建库试剂盒性价比最高，并在生产厂家提供的操作流程的基础做了适合本发明方案的改动，具体实施步骤如下：1)将EndPrepMix解冻后颠倒混匀，组分按照下表的比例加入PCR管中，移液器轻轻吹吸5-6次，稍微离心后，放入PCR仪中，30℃反应30分钟，Holdat4℃；2)加入合适体积的室温的混匀的Beads，稍微涡旋混匀，稍微离心，在室温下放置5分钟；3)在磁力架上放置5分钟；4)在磁力架上，加入160μL新鲜配置的80％乙醇，静置30sec，移除160μL洗涤液；5)重复：在磁力架上，加入160μL新鲜配置的80％乙醇，静置30sec，移除160μL洗涤液；6)低速离心30sec，在磁力架上小心移除余液，置于室温下风干10分钟左右(避免磁珠沉淀开裂)；7)按照下表体积加入的6.3μLddH2O，室温振荡或者吹吸混匀磁珠，于室温放置2分钟，磁力架上静止5分钟；8)吸取5.8μL上清液到新的PCR管中，禁止触动磁珠沉淀；9)将dA-TailingMix解冻后颠倒混匀，组分按照下表比例加入到上一步含有纯化产物的PCR管中，吹吸5-6次，放入PCR仪中，37℃反应30分钟，70℃反应5分钟，4℃反应5分钟，Holdat4℃；试剂名称纯化后的末端修复产物5.8μLdA-TailingMix4.2μLTotal10μL10)将StopLigationMix解冻后颠倒混匀，置于4℃备用；11)末端dA-Tailing反应之后，按照以下配比立即进行Ligation步骤，混合物吹吸5-6次，放入PCR仪中，30℃反应10分钟，Holdat4℃；试剂名称dA-Tailing产物10μLLigationMix1μLDNAAdapterX1μLTotal12μLStopLigationMix2μLDNAAdapterX：VAHTSN801，N802，N803，N804，N805，N806中的任一种adapter12)加入StopLigationMix之后，加入14μL混均的Beads13)用移液器吹吸10次，充分混均，在室温下放置5分钟；14)在磁力架上放置5分钟；15)在磁力架上，移除管中上清，禁止触动磁珠沉淀；16)在磁力架上，加入160μL新鲜配置的80％乙醇，静置30sec，移除160μL洗涤液；17)重复：在磁力架上，加入160μL新鲜配置的80％乙醇，静置30sec，移除160μL洗涤液；18)低速离心30sec，在磁力架上小心移除余液，置于室温下风干(避免磁珠沉淀开裂)；19)加入11.5μLddH2O，吹吸均匀后，室温放置2分钟，短暂离心后置于磁力架上静置5分钟，小心吸取11μL上清至新PCR管中，禁止触动磁珠沉淀；20)P7Primer:CAAGCAGAAGACGGCATACGA21)TaqPlusDNAPolymerase，ET105，天根生物22)将PCR组分按照下表比例进行配置和反应23)PCR循环设置如下：24)加2倍PCR反应体积的室温的混匀的Beads到PCR管中，稍微涡旋混匀，稍微离心，在室温下放置5分钟；25)在磁力架上放置5分钟；26)在磁力架上，移除管中上清，留下5μL溶液，禁止触动磁珠沉淀；27)在磁力架上，加入160μL新鲜配置的80％乙醇，静置30sec，移除160μL洗涤液；28)重复：在磁力架上，加入160μL新鲜配置的80％乙醇，静置30sec，移除160μL洗涤液；29)低速离心30sec，在磁力架上小心移除余液，置于室温下风干(避免磁珠沉淀开裂)；30)用20μLTE溶液重悬浮磁珠，吹吸5-6次，室温静置1分钟，置于磁力架上5分钟，将上清移入新的PCR管中4℃备用，长期保存需要放在-20℃中；31)将合成的探针在室温下融解，待用；如果是干粉，将探针终浓度用TE溶液调整为0.75pmol/μL；32)将UniversalBlockingOligos用TE调整到1rxn/μL；试剂名称试剂数量PCR产物500ngCot-1DNA5μgTS-p5BlockingOligo1μLTS-p7,6ntblockingOligoX＝________μLTS-p7,8ntblockingOligoY＝________μLX＝ReagentY2(I1～I12)的数量/文库混合物中index的总数Y＝ReagentY2(I13～I27)的数量/文库混合物中index的总数且，X+Y＝133)混均上述物质，然后用HeatingBlocker进行85℃烘干，大约需要1个小时；34)将下列试剂按照表中比例在1.5mL管中配置合适用量的mix，在每个含有已烘干的文库DNA的0.2mLPCR管中加入13μL；2×HybridizationBuffer8.5μLhybridizationBufferEnhancer2.7μLNuclease-FreeWater1.8μL35)在PCR仪中95℃变性10分钟；36)将PCR管移出PCR仪器，立即加入4μL0.75pmol/μL合成探针库，稍微涡旋震荡后离心；65℃杂交过夜；37)将杂交后样本溶液转移到含有100μL已活化的链霉亲和素磁珠的PCR管中，吹吸混匀10次；38)震荡混匀之后，将混合物移入HeatingBlocker中，需要在65℃孵育45分钟；39)加入65℃预热的分装的100μL1×WashBufferI；40)稍微涡旋震荡和稍微离心后将混合物转入新的1.5mL管中；41)将1.5mL管放置在磁力架上，直至上清澄清；42)移除上清，加入200μL65℃预热的1×StringentWashBuffer，缓慢的吹吸10次，禁止产生气泡；43)将1.5mL管置于65℃金属浴中5分钟；44)将1.5mL管放置在磁力架上，直至上清澄清，然后移除上清；45)再次加入200μL65℃预热的1×StringentWashBuffer，缓慢的吹吸10次，禁止产生气泡；46)再将1.5mL管置于65℃金属浴中5分钟；47)再将1.5mL管放置在磁力架上，直至上清澄清，然后移除上清；48)加入200μL室温的1×WashBufferI，漩涡振荡2分钟；49)将1.5mL管放置在磁力架上，直至上清澄清，然后移除上清；50)加入200μL室温的1×WashBufferII，漩涡振荡1分钟；51)将1.5mL管放置在磁力架上，直至上清澄清，然后移除上清；52)加入200μL室温的1×WashBufferIII，漩涡振荡30sec；53)将1.5mL管放置在磁力架上，直至上清澄清，小心移除所有溶液；54)将1.5mL管从磁力架上拿出来，加入20μL去离子水，上下吹吸10次重新悬浮所有磁珠；55)将PCR组分按照下表比例进行配置和反应：56)PCR循环设置如下：57)加75μL室温的混匀的Beads到PCR管中，稍微涡旋混匀，稍微离心，在室温下放置5分钟；58)在磁力架上放置5分钟；59)在磁力架上，移除120μL的管中上清，留下5μL溶液，禁止触动磁珠沉淀；60)在磁力架上，加入160μL新鲜配置的80％乙醇，静置30sec，移除160μL洗涤液；61)重复：在磁力架上，加入160μL新鲜配置的80％乙醇，静置30sec，移除160μL洗涤液；62)低速离心30sec，在磁力架上小心移除余液，置于室温下风干(避免磁珠沉淀开裂)；63)用20μLLow-TE重悬浮磁珠，吹吸5-6次，室温静置1分钟，置于磁力架上5分钟，将上清移入新的PCR管中4℃备用，也可以在-20℃中保存一周；典型的产物结果如图8所示，64)将PCR纯化产物送由测序供应商进行测序。5.数据分析1)数据比对分析如下表所示：可以看到，一共30个测序文库，平均有8.92Mreads的数据，由于数据量与测序文库上样的操作差异有关，可能有多有少，不具备比较和统计的意义，但可以看到Q30＝91.53％±1.34％，Mappingrate＝97.00％±3.81％，Ontargetrate＝58.08％±3.07％，符合预期，说明我们测序的质量是很好的；；2)数据覆盖率分析结果如下表所示：SampleMeanDepth1×4×10×20×50×100×250×500×1000×92-L2552200.99860.99750.9970.99530.99410.98910.97420.95120.900192-L2655130.99850.99680.99640.99390.98850.97660.95870.93150.886992-L276298110.99950.99910.99810.99650.98230.95970.911992-L2870190.99740.99710.99670.99610.99570.99510.98760.97210.934792-L2977640.99750.99750.9970.99670.99590.99480.98120.96290.929798-L6155850.99870.99740.99690.99570.99480.99420.99290.98520.966398-L6260590.99970.99790.99720.9970.99540.99450.99310.98720.970398-L6347410.99970.99970.99970.99920.99890.99790.99460.98350.953998-L6455510.99880.99750.99750.99710.99550.99490.99450.98860.968698-L6556310.99860.99730.99710.99690.99650.99520.99370.98670.965800-L7348310.99610.99460.9940.99320.99260.99220.98860.97180.944700-L7453610.99750.99660.9950.99390.99320.99280.99180.98610.971300-L7557740.99930.99880.99840.99750.9960.99570.99470.99190.976300-L7652810.99840.99670.99650.99590.99430.99340.99230.98870.973600-L7759950.99650.99580.99560.99550.99330.99270.99190.98950.976594-L3770650.99680.99660.99580.99440.99310.99060.98270.96450.927694-L3872160.99860.99720.99670.99570.99390.99280.98190.96520.925494-L3977010.99980.99980.99920.9990.99740.9960.98510.96940.93694-L4064230.99680.99670.99650.99620.99430.99180.98630.96990.936494-L4172170.99750.99750.99730.99720.99560.99220.98120.96150.931196-L4955980.99870.99740.99660.99650.9960.99520.99080.97920.95296-L5050230.99760.99710.99690.99610.99530.9950.99370.98460.958196-L5148760.99980.99960.99850.99810.9980.99780.99490.98720.952496-L5247120.99910.99730.99680.99590.99520.9950.99250.98450.950596-L5348290.99870.99750.99720.99720.99610.99530.99340.98270.952102-L8554500.99590.99490.99450.99440.99440.99380.99290.99080.981402-L8656700.9980.99610.99570.99560.99530.99460.99310.99140.985302-L87525210.99960.99930.99860.9980.99740.99640.99440.989602-L8856980.99780.99690.99660.99580.99520.99490.99350.99220.988202-L8973000.99740.9970.99680.99620.99550.99490.99330.99240.9898Average5888.430.99830.99740.99700.99630.99520.98880.98880.97820.9529Std918.780.00120.00130.00140.00150.00200.00380.00790.01480.0268对于遗传性分析而言，高质量的50×数据足以获得可靠的结果，数据分析显示我们在50×时，能覆盖到目标区域中99.52％±0.02％的碱基，完全符合预期。<110>上海阅尔基因技术有限公司(该专利申请的所有申请人的姓名或名称）<120>发明名称<160>879<210>1<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>1gagcagacaactggtggatctgtacaaggtgctggagagcaggggctccgacccaaagcc60cgaaaacccagcctgtccctggacggtgctcccagcaggtgaccttcccacccatgatgg120<210>2<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>2acatatattatattaaaaatatataattgtatttttcaacctacaaaattatctcgagtt60caatatggcaagtcatttatgagaaccaactattgtgttctttacctgaaattgaaaatg120<210>3<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>3cacagtggaaggcttctctgtggacagagactgaagggtgtggaggtatcgaagctgaac60ggcagcaggggtgcctgacagaatctcagctgccatcctcagggactcagaagcagcctt120<210>4<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>4gttagtgaaacctgaattcattcttttttttttaggccttccttgtaaatctccacctga60gatttctcatggtgttgtagctcacatgtcagacagttatcagtatggagaagaagttac120<210>5<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>5aattttaaactaaggggaaccactaatggcatgtatcctttcctttcagatgataattta60ttgtgatgttagagaattcaaggttgcagtaaatggcgtacacagcctggagtacaaaca120<210>6<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>6ggtggcggctgtttcatctttatcatcaggtcttacattcacatcttttcgaccgtgctc60gggtttccaagaggagcagacagaacaaaggccttttccacctgcatccctcacatcctg120<210>7<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>7tgccagaggaaaagctgttcagtatccaagatgcatcaggtccaatcccaggggttccta60gttctccttctgtgcctgctgtaacctcttggccacagcagtgatcagtgctgccccttt120<210>8<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>8aaacagaggatactactggagtggaggagtggaagcagcccagcaggcccactggtagcc60gtgagtgtgaggatagcttatcggtagcggcaggccaaagcattgacattcttgaccaca120<210>9<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>9cctggccctccttgagagtggcatggaggaggaagaagactcgcccaggcccatgggagt60cggatggtggccgcacttgtggggccctgaccccataggcttcttcagcacgccctggcc120<210>10<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>10gcccgttccttcttccccatgccccgctcatgggtcagagggccggtgctggggtccaga60tggtgtcaacagggatggtccctgtcctccccagagacagaagcctgtggcccacggagg120<210>11<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>11tcaatatgactggcagccctgcacctcccattgtgtcctatccttctcttacttgctatg60ccaactcactaccccaacatattgtgattgtttcattttttttttagagacttcgtcctt120<210>12<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>12tttgtatgttattccaggggggaagaggaatccctgttgggcagcagcagctgctgccag60agtccgctggtcatgtggaaaaattgggatcatgagcggaggcatgtgaccctgaacctg120<210>13<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>13ccttagtctacaacaggccttttctgaacttagacgtgcccaaatgacagaaggacccaa60cacagcacctccaaactttagtcatacaggaccaacatttccagtagtacctcctttctt120<210>14<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>14ctatactgagtaatttaaaactctcacccttctttcatcttatctgccttagatttctca60cgtacatccaacttctcttgctctcccataaaagcctgcttgcccgttttcctgtcccct120<210>15<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>15ctagctccaggggcgatcccattcttctccccactttcctaaatgagcagcgttcaaaca60cttttgtagaagaaacccttgccctaaatctgatgctaaaccccagtaggtaaaaaacaa120<210>16<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>16tagtcccccatttgtcttcactctgcaaatgatttggccagtaggtgaggggggataaat60ctcaggctgaccagtgttggcccattcattgtagacctcactgataaggattacatctgt120<210>17<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>17ctcaggctggtgacggtagctgtgaattatgatcaaatgagctggatcaaagtccaggat60agaagtcacagagaactgcgaaggactaatactgaagactaacattaaatgagcactga119<210>18<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>18cccagtgtttggggctctatcagcaagtaggtctatacatactggaagcaggtgacggga60ctgttaagggaaaggggggctgatgaaagatgagaaataataaatggaagaaaaaaaagt120<210>19<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>19tatgagtcatgtttgggtttttatttaaaagattttgatttcattgaacttagagcaacc60gagaacaagaactgggtttcgtggcaagggaaaatcaagtcagatgtatacatttgccac120<210>20<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>20gttctcttaaaacagatgaaacaatataggagagtggatgctggcagaaaaaggcgtagc60attggaaggagtgtttagacagaatggttcctgctcctcttgctccaggaaaagggcctg120<210>21<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>21cccacagggcagaaccacttcctctcatgacaggaaaccaatgaatggggcaggccacac60gaactgggagaattacttcattccctcatgacacccttccatttactcttccttttactt120<210>22<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>22gaccagccctatgagagaagtggacttcgacaccttttttacgtcatccaagatggtcac60actggactccatatactttcagcctggctcccgggtacagtgcgcagctcgtgctgtgaa120<210>23<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>23ggccagccagggtgggcgagacaccataagtggcaaagacatgagaaacgggctcacctt60gggtccccggggtccatcaggcccttgatagccatccaggcctcggcttccctgcaagaa120<210>24<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>24tgatggatgtcgcaggatgagtgctctggcagaggcaagccccacaattccgccaccaac60gatgactatatcaaatgagcttcaaaagaaagtcatctttaaagtaattcatatttacag120<210>25<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>25gctctaacagatacagataacacattagagttcaaaagtgggaatgcagtttggctagtg60caagtggcagatttcctctgccttcatacttgattcatttccaggcaggcatctggaagg120<210>26<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>26cccagtgggatgaccctcactgagagtagcagcaagggaacctgaggttttgtcacactt60tgttcttccagggttgctatcagcactggatcttgttgaagtcaatcctcagttggccac120<210>27<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>27ccaaagacagcaagttcaaaatgcccaagttcaagatgctgtcgtttggggtgtctgccc60ttggcaagtccatcgaggcctcagcggatgtgtctgcgttgaaggtggaggccgacgtga120<210>28<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>28cgtcctacagataccacaacctggatcaggtccaagcaaaacgtccagagtgctacaaaa60tgttgcgttctcagtccaaaaagaagtggaaaagaatctgaagtcatgcttggacaatgt120<210>29<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>29tggcgggcgcctgtagtcccagctactggggaggctgaggcaggagaatggcctgaaggc60gggaggcggagcttggcgggaggaggagaatggcgggaaggcgggagttgcagtgagccc120<210>30<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>30ggatgcaggtgagacctggaccagctgctcagaagagttgcaagtggttctctcgagggc60cgagtgtggttctcaaccggaaactcagtccctgacaacccgaccactcccgggaaacta120<210>31<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>31gggaccggggacctgggacctggcaacaggctgctgccctcaagccacactggccatgac60ggctcttctggggcgcagaggtgtcagctgtcctggtagtggtatgagatcctgctctgc120<210>32<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>32acaaggaaggagttgttttcaccaggagcttctaaaactccctgatggagaagccagggc60gccacccaactccaccgctcaccacaaagcgcccttgccttaagtaagagccaacagcac120<210>33<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>33gtggcctcctgagcgattcacattcccagcctatattcacagatgttaggtcctgcagga60cagggccaccaggctattcagccacaccataaccctagctttaattaaaatagcaactgg120<210>34<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>34tcagccagggtaacatggcaaaatcccatttccacaaaaaaatacaaaaactattcaggc60gtgggggcgggtgcctatagtcccagctactcgggaggccgagatggaaggatcacctga120<210>35<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>35agggcacccaggcatttccagagccatctctgttactattcaggcagccactcccaagaa60cagagcatgggggctgacagcccacatgtctatggatgggccctggaggggactcaggaa120<210>36<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>36acatctgcccaagccaagggtggaggcatgcagctgtgggggtctgtgaaaacacttgag60ggagcagataactgggccaaccatgactcagtgcttctggaggccaacaggactgctgag120<210>37<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>37aactgggccaaccatgactcagtgcttctggaggccaacaggactgctgagtcatcctgt60gggggtggaggtgggacaagggaaaggggtgaatggtactgctgattacaacctctggtg120<210>38<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>38tctgcacgcatccctgtgcactgtccccttgccctccacgcggctctttgggtgaagggc60cgctctgtgggtgaagggcctgggtcctgggagttgaaggtgcagcacagcaaacctgag120<210>39<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>39gaaaagaaaatggatattgtccagtgtctctaagacttgaaaccaaggtcagaaaagatg60tagtgttccctgggtattaggggccatggtgctcatgtttaaatgtaccgtgtgtcccca120<210>40<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>40cctggccgtgttgggagttgtctgccctgtgcatagatgcagatctatccacaggaaaag60ggaacgtcgcgtgaggtttttcatcgcacgaattgttctgtggcgcccttttcccatagt120<210>41<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>41tcaaaaaaaaaaaaaaaagttacgtgaacatctgaagttgtctttgccacccccagttct60agcaagcacagggatcacccctggccgtgttgggagttgtctgccctgtgcatagatgca120<210>42<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>42tcgcgagcccggagcgtggcacgtgggttggtaactgtggcgctgctccgcgtccaccac60cacccctgtcctcctcaggccccctccgcctccacccctgccctcctcaggccccctccg120<210>43<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>43taacacagtgcaaccccgtctctactaaaaaaaacacacaaaaaattggccgggcgtgat60agcgggcgcctgtagtcccagctattcgggaggctgaggcaggagaatggcgtgaaccag120<210>44<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>44ccacccgactgtccctgcacggtagagaggcaggagcgcctctccctgcacggatggtgc60cccggaggctaccaggggcggccgaggacactgatgctgcatcccaggaggacctgtcct120<210>45<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>45ctttactgacattttctcctttactcccacaaatttaggtttaaaatatttccatcagtt60aatctccaatggctaggtccttccaatgaggtctcctgaaaacatgtggcctggatactc120<210>46<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>46gccatccttaaacatcaccttaaaggtgtccatccatgtgtgccctgcttcagacacagg60atgagcatgggtgaaagtttagagctggagataccagtcacccagctctgcatactttcc120<210>47<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>47gtatacagggggaggctggctaatttcccaccatcctatcctgaggtcctagtatgcggt60aaggggggctccatcagtgtgaagggagacaattcaaagtagtggaaatacgtccaacct120<210>48<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>48cctgctccatttccagtctgaaaataagtggaagagctaaagatccacacttaacaatga60aggcatccttactgccagcattgagactgtaaccataaacgagtcctatgttccaatgaa120<210>49<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>49tcaagaccagccttcccaatacagtgaagccccatctctactaaaaacataaaaattagc60tgggcgtggtagcatgcacctgtagttccagctactcaggagactgaggcagaagaatcg120<210>50<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>50aataagttacgataaacatcttttctctgcattcattttcacatatccttaagacacatt60cccaacagtggaattctggaaaaaaatgtttaaaacaccaacagtaggccaggtgcaatg120<210>51<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>51gcctcaaaaaaatgtgtattccactccagttgtaaatatctttagatcagcttttcattg60catttgatggggagaacacagaaatgatagtctgcaaatcatccaggtgaattgttatac120<210>52<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>52aggcatatgtaagcagttattttatgtgataatagaattatagcatgcacttatgtgtgc60atagtctggcatatacttctattatattaaacctctattatttatttatttatttttga119<210>53<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>53gttttgaaacaagatgctaagcatggcagagtttgaagttgcatttcatcttaaggacca60agggaggtaactttaaggttgccagtggtggatccagctccattaggctacgttgtcta119<210>54<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>54actccatctcaaaaaaaaaacaggccgggagtggtctattttgacactccacctcaaaaa60aattaattaattaaaaaataaaatttaaattttaaaaaatcatttcacaaatgataattt120<210>55<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>55actccatctcaaaaaaaaaacaggccgggagtggtctattttgacactccacctcaaaaa60aattaattaattaaaaaataaaatttaaattttaaaaaatcatttcacaaatgataattt120<210>56<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>56cgcctccgaggttcacaccattctcctgcctcagcctcccaagtagctgggactataggc60gcccgtcaccacgcctggctaattttcttgtatttttaatagagacggggtttcacagtg120<210>57<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>57catgagccactgtgcccggctgacaagttttaaataatgttttaaggcatgactttgctt60ccaattggccatttgaacaaagcaattaaatcatctgaattacgcacctaccaaactgcc120<210>58<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>58catgactttgcttccaattggccatttgaacaaagcaattaaatcatctgaattacgcac60ctaccaaactgccacagttactagaaatcagacaactgccaggcacagtggcccatgct119<210>59<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>59ctcagttcaccgcaaactcttgcctcccaggttgaagcaactctcctgcctcagcctccc60gagtagctatgattacaagcacgcgccaccaagtccagctaattttggatttttagtaga120<210>60<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>60tgagagtgtttttttatggtggaagaatgtggatgagaagcctcacgggggtcggagagg60cgtgtcctctctcgggacgctgtctgcaagcttgtccgtccggcaccccgggaaagctcc120<210>61<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>61acactaatttgtgggggagttgcaggaaatctgccttggaattcaggagaaaggcttact60ccatggtattttctggacagactacaaaacttattctgtgtaatagttgcctatcagctg120<210>62<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>62agcgattctcctgcctcagcctcctgagtagctgggattactgatgcacatcaccacgcc60tggttaattttttgtatttttagtagagatggagtttcaccatgttggccaaattggtct120<210>63<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>63aaaaacattggtatcttcttgctgttgatgagcaaatctttggacctgtctcatggtgtc60tttatttgcaaactggttgaatcatgaactgcctggctttggctgccttgccgttgtggc120<210>64<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>64gtgagccaccgcgcctggccttattaatgatttttaaatcagtttctcacaaactctttt60gatcttagatcagtctgtgtttttcataaatgcctcaacggctggctcggttttagaaac120<210>65<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>65gggggcagaactgtgtctgcgagtctagaagtggcctttaaacagtgaatcaatcccaag60aggctgccagttctatgtccaaggttttcccggagttttagggagcgatagaccagcctt120<210>66<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>66cctgtgaggcactggggctgccctgcctgcctcatgtgccccgtgcagtgtggaggcacc60aaccatcgtggcagactctctgatgtcagcgtgtctttcctcaaaaccaagagcctgtgg120<210>67<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>67gacaggtgcccactacatcctctttccctgcggtacgttgtttctgccacatccctggcc60agcctcactcgtggagcatgactgccctgcggctcctcaggtcctgcttctgctctcgag120<210>68<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>68ctggacgggcaggagctgacgcctcgctggacacccaaggcagcccatgtcctgaggtac60agggtttccccaaggaccgcgcaggtgctgcaccccttcccggcatcccgggcacatccc120<210>69<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>69tcacaggtcgtcttcccgtgacgcccagatctgtcctgcaggatggagccagcaccctca60gaggttcgactcgccgtccgggaagccattcatgccctctcgtcttcggaggatggcggc120<210>70<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>70tgtcatgtaatagggctcagtaaacgtcaatttccatagcatttcgagcctggatactga60aatatggggcaaaaagcaggaacatgcccctggtttggctcttgccttcttgcatttcct120<210>71<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>71gaacatgcccctggtttggctcttgccttcttgcatttcctgggtttcctcatttatctt60ttttttttttttttttggccttgttatctttctaccttcagggaagcctctcccttcttc120<210>72<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>72gatgtgaaaggttttggaaaggagatagccctgcagggcaggagggatttttaaggggag60gaagtgggttgggggaaatacccagtgaggagggaaacagatatgtaaattctacccttt120<210>73<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>73ggatttttaaggggaggaagtgggttgggggaaatacccagtgaggagggaaacagatat60gtaaattctacccttttctctacccaggcagatggctcttcttaaggccaataaggatct120<210>74<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>74acatggtgactgtggtggaggactggatgaacttctacatcaactattacaggcagcagg60tgacaggggagccccaagagcgagacaaggctctgcaggagcttcggcaagagctgaaca120<210>75<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>75aggggagccccaagagcgagacaaggctctgcaggagcttcggcaagagctgaacactct60ggccaaccctttcctggccaagtacagggacttcctgaagtctcatgagctcccgagtca120<210>76<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>76gaaagttggtgctgaggatgccgatgggattgacatggcctaccgggtgctggctgacca60cgctcggaccatcactgtggcactggctgatggtggccggcctgacaacacagggcgtgg120<210>77<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>77acatcactgtaccatcccctgggggccttcgaggtgcagtaatattcctggaactcgtag60gtaaaggatgcaaggactaaacaaggtaatgtgtgcacatggtttttcttctttcagaga120<210>78<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>78agggtgccccttcaatggctggtacatgggcacagagatcggagtccgggacttctgtga60cgtccagcgctacaacatcctggaggtaacccagccagcccagctggccagatgaaggtg120<210>79<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>79ctggcagttctaatcgatttctctgtccaagtgcttttgatattatcctgcaacaaatga60ctccccaacaaaaagatggcctaggaggctaggctaaataaaatgttctcttggagccaa120<210>80<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>80cgtggcatgcatcaagcacatcgtggactgcatccgggcagagctacagagcattgaaga60gggtgtgcaagggcaacaggatgccctcaacagtgccaagctgcactcagttcttttcat120<210>81<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>81cgagaagaatatcgaactcttcttttctggttcagcaaaaccaatctatgatgatgaccc60atctcttgaaggtaaggaatagtccgggattatgtttggggcacactttaaaaacagcca120<210>82<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>82ctgtccttagctgattggctgcagcctctgataaggcaaagcaaggcaaggcggcggggg60ggcactgtttctggggcacaaacttcacgttggcctgtctggggctggggttaaagacta120<210>83<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>83atgactggaatgggagaagtggattttctgacatttgatcctatagctaaaatggcaaaa60actgttaagtacgatgtacaagctgtagctatcattgtggtggtattgaaactgctcttt120<210>84<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>84cccttcgcacctctgctttgcggctttaacgcactacaccccacccaccacaagcacata60cacatgctctcaggagtcagagggtcacccagggctagaacttaagccacccagcccaca120<210>85<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>85gggatctatttccatatctacccaaaatctccaagccccttgttctatcagcaggtcaag60agtagagaactgtgacaagctgttctccattctgaaatggatttgactgaacagctgctg120<210>86<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>86tttaacgagggtgttcaaagtaaccatttcccactcccttatttatgagcagcagaatgt60aaaaagcaagaggcttaattttaatgcggtaattttctcatcaaccattctatctaagga120<210>87<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>87ttttccaaatatcatttctgttcaaaatggtaattttaaccttcttagcacccacaaaca60tttcccttctgatatctacttgaactttcagataaaaaaaaaaaagcaagttgcagtaac120<210>88<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>88caactctatagctgactttcaaccatggtcatctgcaaagaagttagtctcagccacctg60cgcatcctcaatgcaaaaagctaagttctaaaaacgtattcttaatgctgttttaaatgc120<210>89<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>89ctgaaagacggctagagtcttgaggagacccaaacagttaaaggttacagacagacttgg60ttccactccagtggtgggtgttttgttttgtttcgctttagctttattaaggtatactt119<210>90<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>90attctagaatttgttacaaatggactcatacaggatatcgtcttttgtgtttaatttctt60ccacagagcagaatgattctgggattcatccatggtgtggagtgtgttactctttcattc120<210>91<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>91ggtctcacacaacactccagggaggcagctgctgcccagtgctgtggacagcaaagcttc60agtgcaggaaattaagattccccctgcctccccctcccccatcctcatcagcttggccat120<210>92<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>92aaacctgagcacattcttacgcctagggcaataaatacatccttgagctacacaggctaa60gcaagagtgagagagggtgatgctgacaggccacatgggagagtgggaagacgtgggctg120<210>93<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>93aattcctagtttgggtcagaagaaaagggaaaagggagaggaaaaaggaaaagaatatga60cgtcagggggaggcaagtcagttgggaacacagatcctaacacagtagctggtacctgat120<210>94<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>94gataaccagcagggcctgtcagaagaggccctggacactgaaggctgggcacagccttgg60ggaccgctcacaggacatgcagcagtgtgtgccgacaactccctaccgcgacccctatca120<210>95<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>95ctggaaaactgagaggtttgcatgttgtaacaatgcaactcaagactatcagaatgatat60gaatatttgtatagatacttatcaaagcaacaatcagagatcaggtccctccaaatgagc120<210>96<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>96ctgctctcttcctgtgtgtctgtctggttacagggtgatctctgcagttgtactgagtgc60aacagctcttggaagagccttctcttacaccccaagttatgcaaaagctaaaatatcagc120<210>97<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>97tgggctcccagggtctcctctctccccttttagcccaggtattcccactggaccaggtgg60ccccacatcatgcaaaccttaatggggaaaacagaattaatactatatcttctcttttct120<210>98<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>98ttcagctcaaaagaaaacacaaattgggctttgatcctgaggtatacacatacagagtca60cggaggttttctgacaaaaactactcaacagatccacaagattcagccctttgagtgagt120<210>99<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>99tgaccatcccaatgaagagcagcagaaagacgtcacactgagagtatctggagaccttca60tgttggaggagtgatgctcaagttagtagaacagatcagtaagttactcttgctttacgg120<210>100<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>100ctctgattcagaagctcgtcaggtgggtcggaaagtgacgtcgccttcgtcttcatcctc60ttccagctcctctgattctgaatctgatgatgaggctgacgtttcagaggtcactcctcg120<210>101<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>101tagggagctggagacagcagagcctggggttgctaagttcctgatgttgcccaccaggct60attgctctgagcagcgctgcctcccagctttctggaaccttctgggacgcctggggtgca120<210>102<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>102caaccaaggaaagtcttccccagtccaaggagcagtcgtgtctgacctacattgggcttt60tctcagaactttgaacgatcccatgcaaagaattcccaccctgaggtgggttacatacct120<210>103<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>103tgtaatgtcacacttgagaacccctctggcttgctcagggttcattgtcttgtgttcatc60atagtctatgatgatgttgggtggatcaacaccaaaccaaatgaacacccctagaagctg120<210>104<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>104aattgatagtccctatgaaatcagccgtgccccagatgagctgcactacacctatctgga60cacatttggccgccctgtgattgttgcctacaagaaaaatctggtagaacagcacattca120<210>105<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>105tctttttcttctttttcttgtctatttacatgcccttgcatgaaacccctcttaaactgg60gatctgtgttctttttgttctggaacatacctaaaataaaaacattcttgaatatcttca120<210>106<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>106catcagctgtcgggctttggagctggaacacttaaactggtccacaagaaagtgctggat60atttgccatctgtttccagaaagcttccatctgtgaaatgagcacaagcagcaagaagtg120<210>107<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>107ttttcccctattattcttcaggtttttttgcccacctccttgtgtatatcttatgggcag60tggatggaagaaaaaaaaagaacaaatggaacgcgatggttgttctgaacaagagtctca120<210>108<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>108taacaatataatctggcatttaactgcctttataattaatgaaccttacttaaatcccaa60ttgtcgacaaaccacgtatgtattcagctcagtccagccatcatcacagacagttcccca120<210>109<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>109tatattttgtttttgtaagtttccacatgtatttttcttaccttcatgttgaagcaatat60cctttccaccatactgctagacgtagctacatctataggtcgcagaagctctgtattttt120<210>110<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>110gttgcagcacactgctgcctcaccattgtcatcgcacgattcggactggaaggagctcag60agactgcacttcagacaggctttcccgggcactgtatggctgggaaggcttttcctctag120<210>111<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>111ctctagggaaaagacccaggcgtccacgtctctgctcgcttcctcacctgtagaatatga60ttctgaaacccacagtggtactgctgtcaaagtcgcccctttcagcctgcacaatacact120<210>112<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>112catcattaccgtttcttcttttgctatgggatgagacactgttgagtattctctaaagtc60accactgaaatcttcctccaaaggaaaacctgtggaaaagccccttatttctgccccata120<210>113<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>113gcaaaggtagcatgatcacttgttccttaaatagggacttgtatgaatggctcgacgagg60tttcagctgtctcttactttcaaccactgcaactgacctgcccgtgaagaggcggacata120<210>114<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>114tgctcttactgagcgcatagctttctcagattatcaggaaccaaatttggaaaataatcc60agaacgctggcgtaggtagctcaaggttccccgcttgcaacatttagtccaaaccagtca120<210>115<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>115tgggaatacttcagtgaaaaatgagatacttattttctggattcatcctggtctgaatcc60aggcttgccaaatataccttgttattgtatgcacaaccaaaagaaatacacatttcatg119<210>116<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>116atgtgatgttgttggatatggccaataccatatgaagctaagtctagctgagtgttagcc60tgggggatactgccaggaacaaatgaggcccagctcccagtaatgggatatgtgtctcct120<210>117<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>117gattaagaaactctactgacacaacatcaggattaaattcactctggacagcagatgtta60ctatatcaaaaccacaaaatgttatcagggcggttccctcagaagacacttactggcaaa120<210>118<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>118agaaataatggaattatattggattatatgcaatatttgtaatttgtgttctgcttctac60aatagacatttttcatgtcattagatattttgtacaacatcaccttaaaaggcggtattg120<210>119<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>119ccttaaaaggcggtattgtatggatatacaataatgtaattaactgaacatatggttatt60tacagttttttcacaagcaaccctgctgtatttctgtgcacagatatagttaaaatcttg120<210>120<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>120gttcaagcaattctcgtgcctcagcctcctgggtagctgagattacaggcgcatgcaacc60acacccgactaattttttgtgttttagtagatacgatgtttcaccgtgttgctcaggttg120<210>121<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>121gtcttgcattgtgagcccatggatgggatctacctctggctgattggggtaggccatagg60acaggacatttaacatccccaaaggaccctgcagaacaagatttgtcagccaggactgca120<210>122<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>122gtgacccagagcgtccaaggggctggtctttccatggccccccctcatcacttcctgaag60cctgctgtagactgctataagagcggccctctctctctcttttttttttaaacaactaga120<210>123<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>123gggaatagagagtgatgggggtaagaaggaaaccagtttagaaagcgtggctggggaaag60actctttgtaaagtgatacatgagcagagaactgagtaagtgagggagataacctagtaa120<210>124<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>124tgggggtaagaaggaaaccagtttagaaagcgtggctggggaaagactctttgtaaagtg60atacatgagcagagaactgagtaagtgagggagataacctagtaagtatctggggacagg120<210>125<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>125aattctctattccatctgtgagaagagagcagagaagtttaaagtgtgtgaccttgagac60ggatttttcttttctgttctctgtcatccgactaaaagcaggaaagcagaggagtcatct120<210>126<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>126tcaccaagttaatagaaggacaatgatgcttcctttttctcctcaaaatcttccttcgct60actaaaaggtgtaggcacatagtttcatcatgaaaaaatattaatcaatagaatctcctc120<210>127<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>127actcttaacagtggcctggaataatataatggcttggtaaggacttaagagaaaatagta60agtgaaagatcccaaaagaactctcaggaatagttggggacacaggtcttccataaaaca120<210>128<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>128ccacatcgctggactcgttgcattggaagggacctggcctgcataagtgtcgaatctcta60tcagtggtaccattaacctcttaacaaacatctattctgtgtggagtactgtttcaggtt120<210>129<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>129cctgtgtgcatattataaaggtttgctaatcaaaagtctagagcacaaaaattaaaataa60ctgagctttgaggtctttagctattatgcctttgattagaagtttagtcagtgtaactat120<210>130<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>130tttcttaataggtgatttggggtaaggactccaaggaaacaagagcgttctgttctaaga60cagaaacatgaggcaaatggagacaaaaggagagaggagaccccaaggacaatagcctcc120<210>131<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>131tcagttaggagcaatcaaagttataaaaatgtttgagaaataaagactccaaacaaaaca60ctgaggccctcatcagtttgtctagggaaatgaggccagtagggggcctgaagatacatg120<210>132<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>132accaccaccaccactacctcctcttctggggcacaagacagaatgcctgtgctagagcga60tatttccacccagcagagctaggcaggaggtggacaggcccagaaggtgtgctgccctcc120<210>133<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>133aattttacaaatatttatggattgttcctttattactttttatatgtgagggaaagctcc60aacttgctttacctttctaagatatcccattttctctataccatttgttgactaatatat120<210>134<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>134accctcatagggtcatcattactgacaaaaagctggcatctcagatccagaccagtgtga60ggcaagtcaagaaggccctaatttagctgtgcaaacaaagcattcctgggtttgatacga120<210>135<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>135tagagaaaggctagttttggtctatcgcagtccatctaaccatcatgcccaggaaacagc60ccaagacttgcctgaagaaagcccaacttacaacttaaggccaagcaactggcaaccact120<210>136<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>136aaggaaagaaaccaggatcctggcagcccaggaagcagagccggtcatgacaacatgcag60ctgatgatgtggggtaagaaattggtactctaaaaactaattttgtgctctggagttttc120<210>137<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>137ccgcctctctgtgcacgtgaagaccaatgagacggcctgcaaccaaacagccgtcatcaa60gcccctcactaaaagttaccaaggctctggcaagagcctgaccttttcagataccagcac120<210>138<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>138caccctgtgcttggacccaggtcgtacgatcatcttcacaacccaccacctggatgaagc60tgaagcgctgagtgaccgcgtggccgtcctccagcatgggaggctcaggtgctgcggtcc120<210>139<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>139accgaagaattcgttatcatgtatggaaattagtgaatgactaaacaaggagctaaaaag60ataaaagagtgggatgattcgactagaatcttcaaaagacataggagaacccctggatat120<210>140<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>140cagctagagtcccctttcctggctgctgctgtctgtgggaacgtcctccacacccttccc60actttccagtatttaaagcgtgcttcctcttctcatccttcaggtcactgtgccagccct120<210>141<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>141aggacagatggccaactccaagcaatgttctttaggtaatatgcttctatagcatacttt60tttaaaattccaaacaaaattttttgcaggccaaagaaactttagaattttaggtctatc120<210>142<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>142atgggttgggactcattttaacttgagagatgtttgaggggccgaaaatgctccagaatt60tgtcgtgaccttgctgtattctacagaccaaactactatgcatctagactgtaccattat120<210>143<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>143caaatgcttaaaaccatgttgcccttgaggtttctcttctgtcttcatcgctttcccacc60gggcgctatacaggtcagggtaccgtgttacacattgtcttcacctgttccgactcctca120<210>144<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>144gaacgtctgtacaagtcgatgaagggtgcggggaccgatgaggagacgttgattcgcata60gtcgtgaccagggccgaggtaagacacactccgactccaaagaggcggctgcaacttctc120<210>145<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>145agggactgcgttccaggcacaggccacgctgaatatggcatcgttcatgttgtagcgggc60atgggggccctgcagggggaccggagggttaatgaagttcctcatgaaatctctccgaat120<210>146<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>146gtactctccttggagccggggtaatgctactccattcttatgagactgcagaacagctcg60tagcatctttgaaaccagatctccttccagcatctttgcctataagaacacagtagaagg120<210>147<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>147gtgcttgaccttcactcccttggtgaaggtccgcttcttgaggacaaagtcatagttggc60ggtagagttcatggcatagaagacgttggcgttttcagggatcttcagctctggtgggga120<210>148<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>148gtgtttcacaggttaccttttaaagaggaagccgaggacgatgccacagacaagggttcc60cacgattaggagcacataaatgtacacagagccgaggttcccgtcgtcagaacctggaga120<210>149<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>149tctgtcttagttggccctgctttggaaccagcacattgtttaataagctctgctcaaaag60ctgacttttttttcagattatgggtcaaatgcctggaaaggtgaggagaactaggtagcc120<210>150<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>150tccagttatactgtatttagggcattctttaatttaccaatgtattgttctgtttaaaat60gtggaaacctgaggaaatgaacaaagcttcactgggttctcatttttctgaagttccatg120<210>151<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>151tcaagacaacaacaacaaaacccagggaaacgtaccttggtgtgaacagcactgaatgat60gtttatgattgtatgttaatcctcttatatttaaaggttaaatgtaaaatatagcctttt120<210>152<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>152gttaaagcaaattactgtgcatatattgacccaataatttgatcaacggaacaagttgca60attaaacttaggttgtttccttgtttgttcacagatccctttttgttgtgtcagggccca120<210>153<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>153gctgattgaataggtgacaacattgccataggtatccattgggggtgcaaacctgtttgg60aatgagagttgtcaagacggttgagtacctgtaggagggattaaggatgttacttatctg120<210>154<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>154catagctagtctttgaacagagtaggtgctccagaatattctaagtgaaggagagaaaga60tttcaaatgtttgtaagcatggaagagtaaggcaatgatggagctactagcaaaggcaaa120<210>155<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>155gtgtttcacaggttaccttttaaagaggaagccgaggacgatgccacagacaagggttcc60cacgattaggagcacataaatgtacacagagccgaggttcccgtcgtcagaacctggaga120<210>156<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>156tgtctaatttatttttctggttactctcagaaataatttcagaaatgagtgtgacatctt60tccctgctgactgaaaccactaactttccacacaagggtaatatatatataggacattac120<210>157<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>157ataaaactttcaggaccctgaaatacagaactgcaaagaaacggcctaagatggttgaat60gctctttatttttctttaatttagacatgttcaaacgttcaatgtcttacatacttagtt120<210>158<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>158caaggacagtgtagcctgaactgggtgggaaaagagaggacagcaaggcctccagtgccc60aagggggcttgttggagttgaggggtgtcactgtagtttaggagatgagggtgtgtaagg120<210>159<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>159ccctctaatatgacctctaggtttacagcctcctgccatcttccagcctccaaaacccaa60aaattcaggccaacgctgaagctttatctgggaggggcatttttataggacccataacca120<210>160<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>160ttgacagttaatatcagccacaataagggaccttcaggagccgctttctagacccagggt60ctctgggaagcctcatcccacaccctctcctgctgtccagggccatctgggagctggtct120<210>161<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>161gagtgtccactgagtccgtttatttggcggtctgtctcactgggtttgcacgacagtttg60gacatctctgtgtggctccctgtggctgaaggcttgtcggattttccgtaagaggctccc120<210>162<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>162ccagggctgtctatgggtccgtgtttgatatttgggtggatctttgggaacgcgagtcca60ggagagggtccattcgtgggaaaaccacccagcattgtgtcacgcgcgtccgtgtgaag119<210>163<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>163ccaccaaacaggcttcttgtcccatccccagtcactaggagagtccaagtgccagggcag60ggctcaaaggtggcgcttcatgtgcaaggccaggtggtcagagcgcgaaaaagcacgtgg120<210>164<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>164acgtgggcagagctggcagcggaaggggcgctgccccgtgtgtttccggtagtggcgggt60cagctcgtccgagcgcgcgaatctccagccgcagccttcccacgtgcaggcgtatggctt120<210>165<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>165tggcttctcccctaggggacaaggaagccataagcgccactgtctgcccagtcatgtccc60cgggtcccctgcatctggccacacccctttactcagcctgggctgggactaggatgaaca120<210>166<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>166cccttcttcccctgtaactacagcgggcgccgcgccctttctcatgtccggggccccgcc60ccctcacctgtgtgcgtgcgcagatgcgccttcaggtgggagctcttggtgtagctcttg120<210>167<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>167ccgcaacccgggtgcgcgcacgtgtgcgctgcctgcctcttgcgcgcccacgaacgtcgg60cctcgcttggatggcgcggtctcggctatcacacctggatcctctgcagtccccccgagt120<210>168<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>168ccagtgcccaccgtcccgggtcccaaacaactcaggaaggagggggacgtggcgggaccg60ggcgcgggtccctggagcccgcggaagagctggaagtgcccttggtactgaggcgccggg120<210>169<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>169tacatcgcggggtacccggacagtagcccgtagggggcgcccgacgccgcaggcactgaa60agcccggtccgcgggaagtagccacccgaggagccggcgccgggccccgggtacaccggt120<210>170<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>170tgcagcgccagcgccttgggctcgggggccggggctggagccagggctgggcccacgaag60gcgtcgggagcccgggctcgcagggcagggcgcacccaacccgagtgatcctccgaaccc120<210>171<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>171aaaagcccagccaccagccccgggccgccagcatatgcgcccagagtctcgggcggcggc60ggatattgcgccccggaggcctcgctgggcgccagagcgcaggtctggggcgcgccaccg120<210>172<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>172ggctccgggcccgagaagttggtgaggaggagatccaggtcccaggtggcgtccgcgccc60ctctcatcgtcctcttcctccccgggctggtcctcagacttcacgtggaggggcggctcc120<210>173<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>173gtggggtcaggaggacccgggcccatgtcctgcgcctcttcggagcgccaccactgcggg60agggagcaggcagctcgaggttcggtggacactggggtgccctgcccagggacatcgcgg120<210>174<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>174taagtctcttgatttcaggtcaagatgcaggtctggaccccaagatctgtgactgtggcc60ctggattccagccagcccacctagaccccaccttctaggccccaccttgaggaagtcatc120<210>175<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>175ctgtgtgtccgggaaggggcccagggcggtcagtgtgctgatggagggcaaggcggtctc60ggctgtggccatggctggctggtgcccaccctgggcctcaagcctcctcttcctcggctg120<210>176<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>176cctcgtgaactctgaggctgtgatagccccttcgagggctcctctctgtccttagctgat60tggctgcagcctctgataaggcaaagcaaggcaaggcggcgggggggcactgtttctggg120<210>177<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>177ttaactgactgagaaaacactaaatttctgtctatttcaaagagaaagacttgataatgg60ctctacggatgtgtgagatcagttttaataggataacttttttttattattatacttca119<210>178<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>178gtgagccaccgctcccagcctagaataacttcttaaatgcttttattgttgactgaattt60atttctcccttgatagtttctactttgggttgataattaaataacagtgttatctctaag120<210>179<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>179cagtgttatctctaagattatatacatgtcttcccatatttttattctagttttttcgtg60actgaattttaccttcacacctaattgtgtaatcgattgtggtatatgcagttaagcatt120<210>180<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>180tatgcagttaagcatttcactttactcttttcaaaaagtatagttgttcaattactgttt60gttttttatttccaagctaaatttaaaagctatatttttatatatcacattattatattt120<210>181<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>181tcacattattatattttagtgagatttagtttttggatttctatttattccactatctta60cttacacatgagtggtattaatttaacatgattttagaatgaagaaaatgaagccatttt120<210>182<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>182aaaatgaagccatttttagataaaccaaaagtaacaatgtatttccagcagaaagagata60atattaaggataatcagaaaaaaatagaataaacttagagagaatgttagaaatgaagaa120<210>183<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>183tgttagaaatgaagaaaagcatgcaaaacattttgtacataagtgtaaacatttcttcac60tatttaataataacactagaaaatctagggagtaaaactatacaaaatatctaaaatata120<210>184<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>184atatatatataattatagattgggaaggggaaaatgaagataaagtgctaaaatttattg60tattgttttggaaaagagtaaacagtcaaatggatatttgtatctgaaaaatcaagaatg120<210>185<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>185tgctaaaatttattgtattgttttggaaaagagtaaacagtcaaatggatatttgtatct60gaaaaatcaagaatgcaattctaatcatcaagatgcatttttttattttttagtttttta120<210>186<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>186gacaagggtctgatttcatttcattttgagggtttcaccctctcatataataaaattctt60ctatatacccttctatcatcacttattactgattatatgccttgatttcagaatcttgcc120<210>187<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>187ttgccaactagattcagaatttgactgggagagaggacaaggaccacttgagactcatat60tttatttccagaatctagcatctacctacctaggtattgaataagaaaaatgaagttaag120<210>188<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>188ttaaggtggttgatggtaacactatgctaataactgcagagccagaagcaccataaggga60catgataagggagccagcagacctctgatctcttcctgaatgctaatcttaaacatcctg120<210>189<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>189tcctgaggaagaatgggacttccatttggggtgggcctatgacagggtaataagacagta60gtgaatatcaagctacaaaaagccgcctttcaaattcttctcagtcctaacttttcatac120<210>190<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>190catactaagcccagtccttccaaagcagactgtgaaagagtgatagttccgggagactag60cactgcagattccgggtcactgtgagtgggggaggcagggaagaagggctcacaggacag120<210>191<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>191gacagtcaaaccatgacccctgtttttccttcttcaagtagacctctataagacaacaga60gacaactaaggctgagtggccaggcgaggagaaaccatctcgccgtaaaacatggaagga120<210>192<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>192aaggaacacttcaggggaaaggtggtatctctaagcaagagaactgagtggagtcaaggc60tgagagatgcaggataagcaaatgggtagtgaaaagacattcatgaggacagctaaaaca120<210>193<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>193aaacaataagtaatgtaaaatacagcatagcaaaactttaacctccaaatcaagcctcta60cttgaatccttttctgagggatgaataaggcatatgcatcaggggctgttgccaatgtgc120<210>194<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>194tgtgcattagctgtttgcagcctcaccttctttcatggagtttaagatatagtgtatttt60cccaaggtttgaactagctcttcatttctttatgttttaaatgcactgacctcccacatt120<210>195<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>195acattccctttttagtaaaatattcagaaataatttaaatacatcattgcaatgaaaata60aatgttttttattaggcagaatccagatgctcaaggcccttcataatatcccccagttta120<210>196<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>196gtttagtagttggacttagggaacaaaggaacctttaatagaaattggacagcaagaaag60cgagcttagtgatacttgtgggccagggcattagccacaccagccaccactttctgatag120<210>197<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>197gataggcagcctgcactggtggggtgaattctttgccaaagtgatgggccagcacacaga60ccagcacgttgcccaggagctgtgggaggaagataagaggtatgaacatgattagcaaaa120<210>198<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>198caaaagggcctagcttggactcagaataatccagccttatcccaaccataaaataaaagc60agaatggtagctggattgtagctgctattagcaatatgaaacctcttacatcagttacaa120<210>199<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>199tacaatttatatgcagaaatatttatatgcagagatattgctattgccttaacccagaaa60ttatcactgttattctttagaatggtgcaaagaggcatgatacattgtatcattattgcc120<210>200<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>200ttgccctgaaagaaagagattagggaaagtattagaaataagataaacaaaaaagtatat60taaaagaagaaagcattttttaaaattacaaatgcaaaattaccctgatttggtcaata119<210>201<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>201tgtatcaattaaaaataaaagaaaataaagtagggagattatgaatatgcaaataagcac60acatatattccaaatagtaatgtactaggcagactgtgtaaagtttttttttaagttact120<210>202<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>202tgtgtaaagtttttttttaagttacttaatgtatctcagagatatttccttttgttatac60acaatgttaaggcattaagtataatagtaaaaattgcggagaagaaaaaaaaagaaagca120<210>203<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>203gcaaataaaagaaactaaaacgatcctgagacttccacactgatgcaatcattcgtctgt60ttcccattctaaactgtaccctgttacttatccccttcctatgacatgaacttaaccata120<210>204<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>204acttaaccatagaaaagaaggggaaagaaaacatcaagcgtcccatagactcaccctgaa60gttctcaggatccacgtgcagcttgtcacagtgcagctcactcagtgtggcaaaggtgcc120<210>205<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>205gcaaaggtgcccttgaggttgtccaggtgagccaggccatcactaaaggcaccgagcact60ttcttgccatgagccttcaccttagggttgcccataacagcatcaggagtggacagatcc120<210>206<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>206tggacagatccccaaaggactcaaagaacctctgggtccaagggtagaccaccagcagcc60taagggtgggaaaatagaccaataggcagagagagtcagtgcctatcagaaacccaagag120<210>207<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>207aaacccaagagtcttctctgtctccacatgcccagtttctattggtctccttaaacctgt60cttgtaaccttgataccaacctgcccagggcctcaccaccaacttcatccacgttcacct120<210>208<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>208cacgttcaccttgccccacagggcagtaacggcagacttctcctcaggagtcagatgcac60catggtgtctgtttgaggttgctagtgaacacagttgtgtcagaagcaaatgtaagcaat120<210>209<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>209atgtaagcaatagatggctctgccctgacttttatgcccagccctggctcctgccctccc60tgctcctgggagtagattggccaaccctagggtgtggctccacagggtgaggtctaagtg120<210>210<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>210aggtctaagtgatgacagccgtacctgtccttggctcttctggcactggcttaggagttg60gacttcaaaccctcagccctccctctaagatatatctcttggccccataccatcagtaca120<210>211<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>211ccatcagtacaaattgctactaaaaacatcctcctttgcaagtgtatttacgtaatattt60ggaatcacagcttggtaagcatattgaagatcgttttcccaattttcttattacacaaat120<210>212<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>212attacacaaataagaagttgatgcactaaaagtggaagagttttgtctaccataattcag60ctttgggatatgtagatggatctcttcctgcgtctccagaatatgcaaaatacttacagg120<210>213<211>116<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>213atacttacaggacagaatggatgaaaactctacctcggttctaagcatatcttctcctta60tttggattaaaaccttctggtaagaaaagaaaaaatatatatatatatgtgtgtat116<210>214<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>214acatacatatacatatatatgcattcatttgttgttgtttttcttaatttgctcatgcat60gctaataaattatgtctaaaaatagaataaatacaaatcaatgtgctctgtgcattagtt120<210>215<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>215ctctgtgcattagttacttattaggttttgggaaacaagagataaaaaactagagacctc60ttaatgcagtcaaaaatacaaataaataaaaagtcacttacaacccaaagtgtgactatc120<210>216<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>216caaagtgtgactatcaatggggtaatcagtggtgtcaaataggaggttaactggggacat60ctaactgtttctgcctggactaatctgcaagagtgtctgggggaacaaaaagcctctgtg120<210>217<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>217caaaaagcctctgtgacttagaaagtaggggtaggaggggaaaaggtcttctacttggct60cagattatttttttcctctagtccactaagaatactgcgttttaaaatcatttccttgat120<210>218<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>218aatcatttccttgattcaagttcctatttctctttatattttgtttgtttaaacctcctt60tactaaaatttactcttctttctctatagcttcccaacgtgatcgcctttctcccatccc120<210>219<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>219cctttctcccatccccctgtactttttccccttgtactaaattaactcctcaggtgagga60aaaacttttgaagtgcagagttctgcttcctgctattaaaagatgtaattaaaacagcaa120<210>220<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>220taattaaaacagcaaaggtagcaagcatttatgaggtcagcgtagggtctcagtgttccc60taagggccctgtcagtcatcctgaatcctgcccctacctggaaacccatgtcggtttagt120<210>221<211>118<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>221ccatgtcggtttagtaaggaaagtgttatacttttactttgcatgtttctcctacttctt60cctttcagctctaacactctgaaactacgattacacaaaataaaataaaataaaataa118<210>222<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>222acaataaaatgaaataaaatttaggttaaccaaaagaaactggatcctctatttctagtt60atcagaaggaaatttacaaatttcttatttccattgctttattctcttaaatgctttctc120<210>223<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>223tctattattgctaaataaatagagatctctcactttttctacctgtctcaaccctcatca60ggtacttgtgaaaaaatctcactctgattattctcacacacgcagaaagtgtttggttct120<210>224<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>224cttctatggctatctggagcctaggttaaaaaattatgcctatgtatgattatagaggta60agagggataaaatttaagtattttctttttatattcattcctctgtaaaaaactaaagca120<210>225<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>225caatgaggatctaggcacacgtgtatccctgagaaaagatttcacatgttgaatcctggg60aaaagacgtctttaaaatattttaaatgttaaaacatgcagatttgacttggctgttaga120<210>226<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>226agcattgttttagatttagacagttttcaagaccctgtttcacatccctgatataagagg60catgtatatgtgaaataaagtgttctgcggaagtttgaatatgtcttttgcaaatatcct120<210>227<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>227tcctgggtcaaagaaaatgcacagactttatgaaattataatataggttatatttatagt60attctgaaagaccaaaattgtcaaagcaagagctttgaaatcctgattggcagaaattgt120<210>228<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>228ttgtcaccttcttaaagacttaccctacaacttcttatgctcagaaatagttttcctttt60tctattttgttttcttttttaaatgatgaactatggatccttctcttgtgttggcaactg120<210>229<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>229actgctgcagataccatcatcctggcttcaaggcaggggttgcttttccaatggtagtta60cttagtgtgactagagtgtaacgcagacttttctttctattacccataataccctgcagg120<210>230<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>230cagggacaaggctgcaagctatactaagaccatcaaaagcccaggcataccaggcaaata60agtttcaagaagcaataaatagtgcaaatttggttatggtcagagcctcagtttcaaatc120<210>231<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>231aatctaaatcagcattcaaagttcctgaaaaactattcaagcttactgacatcttcacta60ttgtgagcttgcttctactctgtgaatggatgccacagcaggtgcaggtctattctactt120<210>232<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>232acttttattccagccccactgaccacaacacacacacacacacacacacacacacacaca60caagtcctcaaaaaagagacagcgagagagacagaggtccatttcctttactccagtcta120<210>233<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>233tctattaatctttcttaagtcctaatgttttatatcagaatggccctagtctgggtatac60ttagaggatgaatattaacttcctccatgaaaatcatgacactcatctatgggagtgtgg120<210>234<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>234gtggttttatcatttgtttcaaaagcagcacttgactagagtatttttatacatgctcta60ctgtttagtctaaaattccccaagtgagacattttagcaatctactgtatatgttcctag120<210>235<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>235ctaggtcaagcacagtctagctacttgctacagacttctctcgcagatacacaatctctc60agtaaacacaactcagcagctctcagaattaattaattaaaatgaaataaaaatgctcca120<210>236<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>236tccaagaaaaccagaacccatagaaacaaaccgcacacacacaaaatagtttggaaatag60gatagtttagttcactttaaaaagttgtatttcttaccaaaaagcaataaagtcaacata120<210>237<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>237catagacagaactttgctaaagtatatgcataattattacagaaaaatttatatttcagt60ctgcaccttgttcattaatatttcctccactgggctcagattttcattcagaattagctt120<210>238<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>238gcttttttttaacctcattaagtgggccatggtgtcaatttatggagagcagaggtacag60tcttcagataaatttgagattgcatctctttagaggtagaatcttggcttcagtctgaac120<210>239<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>239gaacaccctttacaaacatgtaggcattaattcagaggactgctctgaagctcaagagat60ggatgatttaggagactattaggcttaattctcctgacattaaattattttattgaaaaa120<210>240<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>240aaaattttcatgaactcaaattcacattattacgtcctctcttcccttcctctctccctc60tctttcacacacacacacaccctttcattcagacatactgaacatagtttataaagcaac120<210>241<211>114<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>241caacgccatagtgagaaaagaaaaacaaccatttgataaattatcaaataaaattaaagc60caaatcttgaggaattaattccattcctatactttgttttaactttcattttaa114<210>242<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>242tatcatcatttagctcccacactcctagactcttacaaaagctctactctaacaaataat60tttaatataacaacaaggtgccaagtcttttttcatctcttgacctcctcatcttcaata120<210>243<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>243ttcaatatgaagatagcaatgcctagcatatagtaattgtgtgtgctcggcacatgtccc60atccaggtgatgttctcatgaattctctggtatttggatttttagggccaacatcttgcc120<210>244<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>244tcttgcctagactcactgactacttctaatggtgtaggaatagaaggtatagtaagctat60atttgctctttttttttgacttttggagaaaggaatgtagtttgttttccctatcaagat120<210>245<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>245tcaagatcataaggtctacaatctctcttactgtctttcgaataccacacaagtatctcc60ttttaatatcttactcttatgagaacttccctatgctcaggaatgtgaaagtgatcttcc120<210>246<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>246atcttccccaaaatgccctgagtagctctgcttctgatatgtaaaccagtggttcctaaa60tatcttattcagatataaagagttctcagtgcctactatgtataatgacttaaggaaaac120<210>247<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>247ggaaaacacatggatataaaagagcttctgctgccagtcaattcaaaatgttgtgatcaa60aacagttaactataacacattgtcagtatattctggcagtacagacagagttactgtgaa120<210>248<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>248ctgtgaaagcactttcaaacacaaggaaacaacagattctgtttaggtattcaagtaagt60ttaaaattaatcaacatgcatataatacagatttttaaaaatgtatacaactgagaaagt120<210>249<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>249agaaagttctaaaaatccttctaattttacctatggcaaaaatggtgctcaaggaaaaaa60atattactcctatgatcagaaaggaaataactgttcggttgtttactgcatgcttcctct120<210>250<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>250ttcctctttgtatgttgtagcattaacaacaaagaaacactgtgcgatggtattattaat60attgtcctctaattccagaagttctaaagcaaggaataatcattccttcatttactcatt120<210>251<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>251ctcattcgttcattcattcactgttttcttgaataaatattttctttctgcccattgatg60aatttaatatgaggcacagtaggcatgtaagaaggtagagaataggcagaattgcttata120<210>252<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>252aaagcacggagtgtgtgtgtgtgcatgaaataaataagaaaaatataaaaatataaaaaa60tggtgtgggggagggtttggaaagattttttgggtagtatagagaagtttattgtggctg120<210>253<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>253ggggtcaagagaggtcacaagtaatacgtgagcaatgaatcttgactgaaatatgggaag60ataagaggaaattctttacagagatgttctggggcaagtaagaggaggaagctatttctt120<210>254<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>254tggagcaggaacacttgatggggtatagtattatgggctacaatgtgcaggcaaaggaag60gaggaagaaagacaacataacattgtcttgagtaatcattatgcctttaattgagcacat120<210>255<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>255ttattttctcagtaattgttggagtttaatcgtagcattacccttgaggctatgtcttag60ggttgaggtcttccctagaacctctgcagtgccagtattatctttgtatcaagagttctt120<210>256<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>256tgataatttctgctctttggaggtagaagtgtcacccattaatgccttgtacggttccct60tgcttttctcttttcccatgtactctttgtaaaataaacaagtgctccctatctgtagag120<210>257<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>257gcctcaggaaccttcttacacacctggacaaaaaaatgaaataagtgaaattaatcagga60agttgagctgaacattctttattaggcagaagccatacccttgaagtaggcattgtgttc120<210>258<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>258cccaagttcagaaaatagaatctagggaaatagggtcttcttatggttatcaggaaacag60tccaggatctcaatggtacttgtgagccagggcattagccacaccagccaccaccttctg120<210>259<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>259gataggcagcctgcatttgtggggtgaattccttgccaaagttgcgggccagcacacaca60ccagcacattgcccaagagctgcggagaagaggtaggcagatacatgcatatggttaaca120<210>260<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>260agagaaataaagactggcttctgagaaactgagccaacacccatttttttctgcccaaat60cttagacaaaactgatccccaggttattcccatcagcataaataagtacatatatgaat119<210>261<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>261atgctgtataatactatatacaaattaattccaaattagttttaattttgtatgtgtata60tagcatatacaaattaattactataaacagattaatagatacaaattaattgattaatca120<210>262<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>262tcagtgtgatgatgggctgtctcctagcaacgacttctgccccacctccagtgtaactgc60ctagtctttcataatcaaatattcactttcctttccattccatttactacagaatttata120<210>263<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>263ataaaattccaattattccttattgtaaaatgatttatagcctctaaaacagtattctat60gcctctcatctttgagttggagcctctcccatacccatgtggagagacaaaaggattatt120<210>264<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>264attctaagtgcagaattagcaggtgagagctggtatgcataatttgagttgttgttagag60aaggaaaaatgaagggagggggttgggagagaaagacaggatattaaataatttaaaata120<210>265<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>265atagcaagattgtgaggaaggaaaaaatgcagaatatttaaataaaaaattaacaaaatt60ttagaagcattaaatgataaaatatagtaaaatgacaaaaatgtgggagaagagcaggta120<210>266<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>266gtaggtaaaagaaccaaaatgtaagattagaaagtaaaaagagaaaagtgaagcatctcc60tggactcaccctgaagttctcaggatccacgtgcagcttgtcacagtgcagctcactcag120<210>267<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>267cagctgagaaaaagtgcccttgaggttgtccaggtgagccaggccatcactaaaggcacc60tagcaccttcttgccatgagccttcaccttagggttgcccataacagcatcaggagagga120<210>268<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>268ggacagatccccaaaggactcaaagaacctctgggtccaagggtagaccaccagtaatct60gagggtaggaaaacagcccaagggacagagagtcagtgcctatcagaaacccaagagtct120<210>269<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>269tcttctctgtctacacatgcccagtttccatttgcctccttgagcctctcttataacctt60gataccaacctgcccagggcctcaccaccaactgcatccacgttcactttgccccacagg120<210>270<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>270agggcattgacagcagtcttctcctcaggagtcagatgcaccatggtgtctgtttgaggt60tgctagtgaacactgttatgtcagaagaaagtgtaagcaacagtcgactctgccctgcct120<210>271<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>271ccttttatgctggtcctgtcctccctgctccagtgagcaggttggtttaagataagcagg60gtttcattagtttgtgagaatgaaaaatgaaccttcattccactattcccttaacttgcc120<210>272<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>272gccctgagattggctgttctgtcatgtgtgtcttgactcagaaaccctgttctcctctac60atatctccccaccgcatctctttcagcagttgtttctaaaaatatcctcctagtttcatt120<210>273<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>273atttttgcagaagtgttttaggctaatatagtggaatgtatcttagagtttaacttattt60gtttctgtcactttatactaagaaaacttatctaaaagcagatgttttaacaagttgact120<210>274<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>274actcaatataaagttcttctttgcctctagagatttttgtctccaagggaattttgagag60gttggaatggacaaatctattgctgcagtttaaacttgcttgcttcctccttcttttggt120<210>275<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>275ggtaaattcttcctataataaaactctaattttttattatattgaaataaatatccatta60aaagaatatttaaaaaatgaatagtgtttatttaccagttattgaaataggttctggaaa120<210>276<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>276aaacatgaattttaaggttaacattttaatgacagataaaatcaaatattatatacaaat60attttgaatgtttaaaattatggtatgactaaagaaagaatgcaaagtgaaaagtagatt120<210>277<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>277atttaccatattcagccagattaaatttaacgaagttcctgggaatatgctagtacagaa60catttttacagatgtgttcttaaaaaaaaatgtggaattagacccaggaatgaagatccc120<210>278<211>118<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>278cccagtagtttttcactcttttctgaattcaaataatgccacaatggcagacaaatacac60acccatgagcatatccaaaaggaaggattgaaggaaagaggaggaagaaatggagaaa118<210>279<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>279atgactttatttgtatatagaaagatggatgatgtgcctgagattctgatcacaagggga60aatgttataaaatagggtagagaggagccatgaatgacctttaaactttgttacaagtta120<210>280<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>280cctgagattctgatcacaaggggaaatgttataaaatagggtagagaggagccatgaatg60acctttaaactttgttacaagttatttttctgtaacctggaagccaacgaaagatattga120<210>281<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>281gctgggcttctgttgcagtagggaagaaagtgacaatgccatttctattatcagacttgg60accatgacggtgatgtcagtcgtgaacacaagaatagggccacatttgtgagtttagtgg120<210>282<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>282acatttgtgagtttagtggtacgataaaatcagaaatacagtcttggatacattgtattg60tatgcactcttgtaaaatgcaaaaagatgtacttagatatgtggatctggagctcagaaa120<210>283<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>283tggatctggagctcagaaagaatacaaccaggtcaagaatacagaatggaacagaacata60caagaacagatcataatgtgctgtgtgaatcactaccactacctgttaaaaatgacagat120<210>284<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>284cctgttaaaaatgacagatgatgtacttcatcaatatctccttaaaatcttagaatgtgt60ttgtgagggaggaattatgtttccaattcatatataagaaaattgattctaaaaaaaatg120<210>285<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>285attgattctaaaaaaaatgttaggtaaattcttaaggccatgaggactgttatttgatct60ttgtctgttaattccaaagacttggcttttcactttaattctgttctacctgaaatgatt120<210>286<211>118<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>286tgttctacctgaaatgattttacacattgggagatctggttacatgtttattctatatgg60attgcattgagaggatttgtataacagaataaggtctttttttcttttctcttctgag118<210>287<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>287ctgagccaccgcatccagccaggataaggtctaaaagtggaaagaatagcatctactctt60gttcaggaaacaatgaggacctgactgggcagtaagagtggtgattaatagatagggaca120<210>288<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>288atctactcttgttcaggaaacaatgaggacctgactgggcagtaagagtggtgattaata60gatagggacaaattgaagcagaatcgaactgttgattagaggtagggaaatgattttaat120<210>289<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>289ctgtgaatccaagagtgtgatgaatacaaagttaaatgaaggacctttaatgaacaccaa60catttaatgtgaaatctcaaggaagtatgaagtaagacatagtccccaaaatccccgatg120<210>290<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>290agacatagtccccaaaatccccgatgattttagaactcagtatcgattttaattagtgta60atgccaatgtgggttagaatggaagtcaacttgctgttggtttcagagcaggtaggagat120<210>291<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>291tgttggtttcagagcaggtaggagataaggttctagattttgacacagtgaaaagctgaa60acaaaaaggaaaaggtagggtgaaagatgggaaatgtatgtaaggaggatgagccacatg120<210>292<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>292tgtatgtaaggaggatgagccacatggtatgggaggtatactaaggactctagggtcaga60gaaatatgggttatatccttctacaaaattcacattcttggctgggtgtggtggctcacg120<210>293<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>293ctcagaaaaaaaaaaaaaaagttcttgctaacctgaaaaaataaattatttgagctttgt60acctaattcataattttcagataatgaatattgagatgatatatgcacagaacaatgcct120<210>294<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>294atatatgcacagaacaatgcctagagacacattctaagtgtgacattcttaaatgccagt60gctctccacaattctaatctcagttcactgctgtttgaattctgtgttttcatattatct120<210>295<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>295attctgtgttttcatattatcttatcaatacattaatcattgcaataatcactgcacact60gtaattattcatttactggacacatcctagtttccttctgtcaattaccattcatgtctg120<210>296<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>296gatggaccctaactgatataactaataaactgacttctgatactatgtcttattagtgta60tgaaattctgatgtgaataaatgcatgacacatgcttgttgactaatcaaactatagcag120<210>297<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>297tgttgactaatcaaactatagcagaggcagaggaaggaacctcatgacctataaatacta60agatatcacatagtcattttagaaccaaaggttcctcagtttaggtctcaaacaaacttc120<210>298<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>298cagtttaggtctcaaacaaacttctctatggatagtgtaatactcataatgtagaaaaga60gagatctaattttggataatttaatcttttttttcatctccaaatactagggaaataaga120<210>299<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>299aatgaacagcatgtacaaagctaacagagtcaaatgcagaaatccaaattctctagattg60actggggtaattttgtcaatgcactcaagtatgcatctgtaacagtgtgtgttcttatgt120<210>300<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>300tgtgtgcatggaatgtttgttcatggagcataagaaattgtgtagacatatagacacatc60tgtatgtgtatatcagagaatgtttacattgctacaagattttatatgactacatgcaca120<210>301<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>301acaagcattcatgctacatgtcagtttggtatatttttcctgtaagatgtgtacttatgt60gttttccactaaaggtgaatgtgaaaactcctcatcgagaaatgaacaataagtaacaca120<210>302<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>302acaggaaattcaaccctcatctcttcatttaaaatacagagtgacattcagaagggcaag60ggatagcacaagtgtgagattttaaagtgtgattgtttggacacagtaattattcaaaga120<210>303<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>303agaatgtgcttaattaatgtatgctacaagacagcagttgagtgattattgtacatgagc60aactggtatttattctgctttgtgggttattagtggggactcaaaaatatgacaaaggaa120<210>304<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>304gaatttcagaagctgttagatggtagcaccgcctatctatgtgctcccactcaagagata60tggtgaggtgagctctttggggtggacacatagaggaaatactttgagaaagaggttttg120<210>305<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>305ttgggattaatgaaactggagaagaaagggtattatatcttctaaaacctctttctttga60ggttttaggtttgagggtgctacatacttcctaagggtcttgggtacaggagtttgaagt120<210>306<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>306agtgattgccacagaatggctacgttcattgccagatccaaacagggggcttgtaggcat60ttgctgttctgtcaataaatttccttcttttcattcacagacagggattttagctgtcat120<210>307<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>307catctctgactctctgtttcacaatgttttccagttctgtgcaatcactgccacaatggt60ctcttactcgattttttttcttaacttcattgtttccatcaacttcagttctttatccat120<210>308<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>308catcacctcaatataattacagcaagctcctctgactatacccaagttagactttgtcta60atcagttctatatatatatatacatgtgaatcaattttctacgtttccctatttattatg120<210>309<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>309atgtcactctcatatgcaagaaacttcagtgatttttgctcaaaacgatagctatttttc60ttacttcatctggtctctgcatccagtttccctaattttatatcatcctgcctcttttaa120<210>310<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>310taaatgtccatattctcctctatcaacttgacttaacgtgctgtttcctaaatctcagcc60ttttaatctgctgtttgctcacataaacaaaaatcagtggttttcaatattgattgctaa120<210>311<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>311taataattttttattcataaaaattgtatatatttatgaatgcacacatgtgtgtgtata60tatatagaaagagaataaaatcactaccactaaaaacaataaaacttgtacatatttata120<210>312<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>312atagaaacagagagctgaacaaagagatttattatttattgggtagtgtgataaagactt60tacaggtatcaattcaattagttcttacaaaaatcctttaaggaaaatacatatgataaa120<210>313<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>313aaatctatcatatgcacagcttaatggaattataaatatgtttcaggtcacagaggtagc60agatgaagtacagatgaaaaccaagacagccagttcacatgccttagagataattctcta120<210>314<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>314ctattaataccattgaagacgttaagagaaagttcaaggtttggcccttgattggtctct60aggaagccccatccccacttcattataaataataaaaaatatgttgtttaaaataagtag120<210>315<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>315tagaagtgaactgcagtcaccaaatgagctatatcctgagtttcatacaaataatagcct60atacagaacttctaatttgagtcctaacatacctctacacactaccaacaatcctcttac120<210>316<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>316tacacctccaaagagtacctccattgacctccctttctgtaaaaacattgtcttattcta60gagacgatttccccttcctaggagtaactaccccactaaatccacccacgagttctctct120<210>317<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>317tcttttcttgcaggattgcaagaaagtatcttctctgtccttaaactcccattctccaac60attctcatttccatcagaaatagtgcgtccttttggctgaatcagggtaaaatataaaga120<210>318<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>318agacagaaaaagagtacaatgatatttcttagagagcatatttctttattctatttttat60catgcaggaactgaatcagcaggcaggatactgctcttctccccaacctcccccatctaa120<210>319<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>319taaaggagatgagattttgggacataggtacaaacatagtggaccataggtacaaacata60gtggacagggaactcagtggtcttgtgggctacagcattaaccacagcatttgttagtta120<210>320<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>320ttactgccaagaagcctgtatctgtagggtaaaatcctcgctgaagtgggttgccaaaac60aatcaatatcacgttgcctaagagctggggagggagtgaagataaaaaagaaaatggtac120<210>321<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>321tacatagtgaatagaaggcctcaagctggacttgcagtaaatagatataacacttacatc60ctttttcaccagagtttgagcaactctcaccattatgggctagatatcagcttcaatatg120<210>322<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>322atgactggcagccctgcacctcccattgtgtcctatccttctcttacttgctatgccaac60tcactaccccaacatattgtgattgtttcattttttttttagagacttcgtccttttaaa120<210>323<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>323aaaaagtaggataatagtacttcaaggaacagtaatggataggataagtccccagtcatc60acatacatacatacatacatacatacaattttcccaaacactcataacaaagaatcctgt120<210>324<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>324tgtaccatgcgtacaaaagtataccatcatcattcggagggaaacaatcctctttttaac60agcttcccactactttgttcagttgatctttttctaacctccaggactatgcagaaaagt120<210>325<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>325agtgactattaatttttatagaaaatttcgctgaccaaaggaaagatgttattttctcta60tctcaacttctgttccctcatccaaaaacactcagtttgattttggccagaattttttat120<210>326<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>326tataagatgtgtttttcagagctatcaaatggtaagtggccttccattattcatagtcct60tgctctaccaaattttagttatgttatttacagcaacataactctcaaaatcccactgct120<210>327<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>327gctgaaatatcatatcccatagctgactcataacacaagagaaagccacctctgctttca60aaagtacccatagtgcaaatatctaagggtaaagaagaaagcgtgagtgtacttactact120<210>328<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>328actcaccaggaagttctcagggtccacgtgcagcttgttacagtgcaggtcactcagtgt60agcaaaggtgcctttgaggtcatccgtgagcataacagcttttccgaaggagatcagcac120<210>329<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>329caccttcttgccatgtgccttgactttggggttgcccattattgcacagtcagagcccag60atatccaaaactttcaaagtacctctaggtccatgggtagacaaccaggagactgtggga120<210>330<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>330ggatagtcataatcacagagcaggtgcaaagtcagactatgtaagacaacgggctaatcc60ctctttcagaaacactttctgcctttctgcaccttgtcccggcttccagtacctacctgc120<210>331<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>331tgcccagaatctcacctccagccttctcaccttaaccttgcttcacaggctggtggcagc60agccttcttgtcagcagtgaaatgcactacagtgtcagatctgggagtttcctggtgatc120<210>332<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>332atcacagatgagccagaagcatgcctgcattgctgcttcatgtgtggctttttacttctc60ctctctggcccccagccctttgcctctcccagtgaaatgaatctattgaccagccctttg120<210>333<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>333ttgcctccctcagtaaaatgaatctattggtcaagggtgggttgtgactccaggggtggg60gtttgggcaaggaagttttgcaagatggacattcgagtttctgatagaatccaggtggcc120<210>334<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>334gccttctcaggggaactttgctgttcaggcttaatttgaaactttacttccttcccctcc60attttcctacactacccccaccatccagtgtgcagtttatttctcaaggacttcgccagc120<210>335<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>335agcagccgctaataacctgaatgctgacaaataggaataagttacaactgaaaaggataa60gaattacgaatatcttagccatcaattcctggatcaggagttgtgacaatgtaacaacgt120<210>336<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>336cgtgttatcctgttattcatccaggctttatgtggaagaagccacagcctttcttggttt60tcaattctcttgagactacattgaatacacaatttcatcagtttttttttctttctttct120<210>337<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>337gtgagccaccgcgcccggccaatttcatcactttttagaatagaaataaacacctctatc60cagcatcaacttggaagaaagcagaataagaaacaaactagggaagtaaggggaaaactg120<210>338<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>338tgggttttattactgtgttttttaatccatttagtagtcagtgtacttatctgaacaaag60gagatttcctctgaatcattgaacaatagtccatgtcaaatcctacatatctacaaaatt120<210>339<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>339ttatgccagaacatctaatagtgttgggggagaagtgtgctgctctgttcaagcaagagg60ataggagattccgtggcccgtgctgggcattaggtcatttgtgtctggcacaggcttgat120<210>340<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>340atctatagtctaatgctgtgtttaacttgtctttatatctaatcaggcaaagacattctt60cactgacaatattccacaggctgctgcacgtgtctcatgtgctgcacgtctcatgcgtct120<210>341<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>341ctcaaacaagcaatttcaggaatagacagggcacacttccaccggcagagagaagaacag60tttattttatattcttaaggcttactgtcctcatacttagaggttcaggatgctggtttg120<210>342<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>342tgtgtgttacccctgagataaatccttacaagaaataaagtttaggaaatcacccccatg60tgtatttcaaggagactctaaatttcaaagagttaaacccaatatattaaagctgaattt120<210>343<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>343ttctgatattagagacacaatattttagtctacttgatatagttgagaggcagttacctg60ttttacttaggaacatggggaaagtttgtagtgacaaacagtttgaggcaaaaccaagat120<210>344<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>344attatctttaagagcagagatcgatgatatgaagaaaaagaagtggcaactttgactata60tgcaggaaacacatttatattgagttgtggggactggcctcagaggaaacttcaggtcat120<210>345<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>345atgtcctttaatggccctaaaactcattcccaaaagaatttctgttcattgccatacctc60atatccttaggtacatacatctaaaaccctgcgtaccagtgaacagctgccccatctttc120<210>346<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>346tccatcagccaaccaggaattcagcagttactgctaacttccacttttctctcacccgct60ccaggaaaagtgacctgcagtcactttcctggaagtattgattctttcttgtttgtggct120<210>347<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>347ctgttccccatttccaattgttttccatgattattgcttctactgtgatctatagactct60tatatcatcaataccaggttatcattgcagttgtcaacttctctctgttgcatcttatgc120<210>348<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>348gcattaattcaacaaatacatattagattccatatgtcatccatgaagtttcattcatat60gccatccatttttcttaattctgagaatcttacatgaactagacagacagattctctggc120<210>349<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>349gctaatggtgccctcactatagtgagcagaggagaccagcatacatactaaaagaaatga60attaataagagatttcagatggtattatatgacttgaagaaactgcatattgtacctaca120<210>350<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>350aagaaaaaaagaataaagaactttacatttcactgtatgtaaagacattacaaggctaga60gtaaagcatgttgaagtaaaaataggagaaatcaaagttagagagaagggcgcaggctta120<210>351<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>351taggagaaatcaaagttagagagaagggcgcaggcttattatttgggtcttatagatgag60agtagtagagtaggtattttatactgaaacataggggacgaggggagctttgcaaacctg120<210>352<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>352actgaaacataggggacgaggggagctttgcaaacctgagataaacatggtctgtagtcc60actcaaaacccaagcttatttttttctccttcttcatctgccttactcagtgcaaggtgc120<210>353<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>353caaacattaggtccgtaacaccatcatattaaactcttacttatagagatgcactaacat60ccaactatacaaaaattccattaagtaagccttccaattaatgttgtacaaattcttccc120<210>354<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>354ttcccactacattttgatctcacagtgctggtctgtttctcagacataacatgctcatgc60tgacttgtgagcctctgctgattcatttcttacacctaagtccccacctcccccagagtc120<210>355<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>355gagtcttacaatgaggtctctcccttgaaatgctgtgaccaatctgcacacttgagggca60tgggattaatttcactttcttaggcatccacaagggctgtgaaaagctaagtgccattag120<210>356<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>356attagaaatagtattcctcctaataaaatagaattgctacacctgactaaaccttgaatt60cctaaagcttggaacactttcccttccttaagaaccatccttgctactcagctgcaatca120<210>357<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>357aatcaatccagcccccaggtcttcactgaaccttttcccatctcttccaaaacatctgtt60tctgagaagtcctgtcctatagaggtctttcttcccaccggatttctcctacaccattta120<210>358<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>358atttactcccacttgcagaactcccgtgtacaagtgtctttactgcttttatttgctcat60caaaatgcacatctcatataaaaataaatgaggagcatgcacacaccacaaacacaaaca120<210>359<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>359gcagaaatacacatacacacttccctcaatataaaccctttgtggctcatatatttaaaa60agatgtaaaaaaaagagctgaagaaaatcatgtgtgatctctcagcagaatagatttatt120<210>360<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>360attatttgtattgcttgcagaataaagcctatccttgaaagctctgaatcatgggcagtg60agctcagtggtatctggaggacagggcactggccactgcagtcaccatcttctgccagga120<210>361<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>361ggaagcctgcacctcaggggtgaattctttgccgaaatggattgccaaaacggtcaccag60cacatttcccaggagctgttgagatgaaaggagacaataaagatgaacccatagtgagct120<210>362<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>362gctgagagctccagcctggcctccagataactacacaccaagcttccacccagaatcaag60cctatgttaacttccctcaaagcctgagattttgccttcccattaaatgcaggtagttgt120<210>363<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>363tgttccccttcaagcactagtcactggccataatttaaatcttgctatcttcttgccacc60atgaaccctgtatgttgtaggctgaagacgttaaaagaaacacacgctgacacacacaca120<210>364<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>364cacacacacacacacacacagagctgactttcaaaatctactccagcccaaatgtttcaa60ttgttcctcacccctggacatactttgcccccatctggaattaaaggatataagtttgta120<210>365<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>365gtaatgaagcattagcagcattttatatgtgtccagctgatataggaatagccttagcaa60tgtatgtttggccaccaaagttccccactttgactgagccaatatatgccttctgcctgc120<210>366<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>366tgcatctttttaacgaccatacttgtcctgcctccagatagatgttttaaaacaacaaaa60atgagggaaagatgaaagttctttctactggaatctaataaagaaaagtcattttcctca120<210>367<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>367tcatttccacctctcttttctcaaagtcaaaattgtccatctagatttttagaggcactc60cttaggccctaaaacattaccactgggtctcagcccagttagtcctctgcagtttcttca120<210>368<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>368tcacccccaaccccagtatcttcaaacagctcacaccctgctgtgctcagatcaatactc60cgttgtctaagttgcctcgagactaaaggcaacagggctgaaacatctcctggactcacc120<210>369<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>369accttgaagttctcaggatccacatgcagcttgtcacagtgcagttcactcagctgggca60aaggtgcccttgagatcatccaggtgctttgtggcatctcccaaggaagtcagcaccttc120<210>370<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>370ttcttgccatgtgccttgactttggggttgcccatgatggcagaggcagaggacaggttg60ccaaagctgtcaaagaacctctgggtccatgggtagacaaccaggagcctgtgagattga120<210>371<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>371tgacaagaacagtttgacagtcagaaggtgccacaaatcctgagaagcgacctggacttt60tgccaggcacagggtccttccttccctcccttgtcctggtcaccagagcctaccttccca120<210>372<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>372ccagggtttctcctccagcatcttccacattcaccttgccccacaggcttgtgatagtag60ccttgtcctcctctgtgaaatgacccatggcgtctggactaggagcttattgataacctc120<210>373<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>373ctcagacgttccagaagcgagtgtgtggaactgctgaagggtgcttccttttattcttca60tccctagccagccgccggcccctggcctcactggatactctaagactattggtcaagttt120<210>374<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>374tttgccttgtcaaggctattggtcaaggcaaggctggccaacccatgggtggagtttagc60cagggaccgtttcagacagatatttgcattgagatagtgtggggaaggggcccccaagag120<210>375<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>375gaggatactgctaattttttttatagcctttgccttgttccgattcagtcattccagttt60ttctctaatttattcttccctttagctagtttccttctcccatcatagaggataccagga120<210>376<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>376ggacttcttttgtcagccgttttttaccttcttgtctctagctccagtgaggcctgtagt60ttaaagctaaagcatgtaccaatttttgaaaagttcagggattgtgaaatgtgttttagg120<210>377<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>377aggcataggtccaggatttttgacgggacaaatcttagtctctttcagttagcagtggtt60tctaaggaaaaagtgctatacttctttttgaatatactctttgtgacttttgccattatc120<210>378<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>378atctcttaatttctcaatagtgcagtgaaaacaatttctataaagccacagtttcagcgc60agtaatagattagtgttacataatataagacctaatgcttacctcaatatctacttatcc120<210>379<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>379tccgtacctatttgaaataaatcatgactgtttcatcttagaaaaatatttgattccata60ttcaggtatgtatgtatacaccagatgatgtgtatttaccactggataagtgtgtgtgct120<210>380<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>380gctggctgatgacccagggttttggcgtagctcttctatgctcagtaaagatgatggtag60aatgttctttggcaggtactgtggattagaattaattatcttgtataaatgctaggttca120<210>381<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>381tcacttctcagggaatcttactctaagacataagatgtgcgtgtacatggaaaacaactc60taaagaggcaagggttgtttttattgactaatagtccacacactattataactcgaatat120<210>382<211>112<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>382tattagtgtactttagacagctttatttctaacacagtgctgtttctgacatattggacc60attaacagggtaggaagtatttatggtggttttttggttctgttttgctttt112<210>383<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>383gttagtttgtttttgtttttctctgaaagtgatccatgatctctaaccttgctagattat60aatgccagaagctctggaattctggcttatcggaggcaagctgtatcttcaaattagttt120<210>384<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>384ctctggaattctggcttatcggaggcaagctgtatcttcaaattagtttatcccctaagc60tatcaggttgattgaaattattataatattggtgaaattctttcatccttcatgatcctg120<210>385<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>385ttgaaattattataatattggtgaaattctttcatccttcatgatcctgtgtaaagctta60tatctgctcattgatacagatggctaaaaggccagaaagacacacatttacccatgtaac120<210>386<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>386attttttataaacttgttttactaaaaaaaaaaaggacaaagaaagaaagtgcgaattgt60gaaatggtagtgagtgatggcatttgaagtgggtcctttatgatttgatggagccaggca120<210>387<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>387cagaagacgtttggagaaagaagttcctgaaagtaggaagggcatgtggaaaactctgag60gctgaggaaaaaaaagaaagaaagaaatataaagaaagaacttgacatttcactgtatat120<210>388<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>388ataaacacattacaagcctaaagtacgttgaagaaaaaatagaattcaaagttagacaga60agggctcaggcttactatttgcatcttacagatgagagtagtagagttggtattttattc120<210>389<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>389tctgaaacacagaggacaagtggagatttgtaaacctgagataaacatggtttctaatcc60actgaacaccgaagcttatttttttctctttcttcatctgccttacttagtgcaaggtgc120<210>390<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>390caagcgttaagttcataacaccatcacattaaactaaactcttgcttattaacgtgcatt60aactttcaattatataagaactccagtgaatctgccttctcaattaatgttatacaaatt120<210>391<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>391cttcacactatattttcatctgaccgtgctgttctgctgctgagacatgacacgctgatg60ctgacttgtgagcttctgctggctcatttccttcacctaagtccccacctccctagaagc120<210>392<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>392ttacaatgaggtctcctccttgaaatgctgtgaccagtctgtagacttaagggtatggga60ttaatttcacctctttaggcatgcgtcaacacttaaaatgaaaagttccttagtaaagta120<210>393<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>393aggatcacttcattgtagttaccgtggaaagaaaaacctgtttcctgctctgatctctaa60cacctcaacctccctgtagagcctcacaagggctgagaaaagccagatgccgttggaaat120<210>394<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>394agtattgcccctaataaaatagaatggctatccctgcctaaaccttgacttcctaaagct60tggaacactttttcttcgttgagccccttcctcgctgctgtgctgcaatccagggaaggg120<210>395<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>395ggttcagcccccttcactgaacctttccccatctcttccaaaacatctgtttctgaggag60tcctgtcctatagaggtctttcttccaaccagatttctcctgcaccttttactcccactt120<210>396<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>396gcagaactcccatgtacaagtttctttattgcctagttcttttatttgctcatcaaaacc60cacatctaacgtaaacaaaaaagtgtggagtgtgcacatgacacaaacacacatagccat120<210>397<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>397gtataaatacacataaacacatccctcaacataaaaccctttgtggctcatatatttaaa60aagacataaaaaaagaactgaagacaaccatgtgtgatctcttagcagaatagatttatt120<210>398<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>398atttgattgcttgcagaataaagcctatccttgaaagctctgcatcatgggcagtgagct60cagtggtatctggaggacagggcactggccactccagtcaccatcttctgccaggaagcc120<210>399<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>399tgcacctcaggggtgaattctttgccgaaatggattgccaaaacggtcaccagcacattt60cccaggagctgttgagatgaaaggagacaataaagatgaacccatagtgagctgagagct120<210>400<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>400ccagcctggcctccagataactacacaccaagcttccacccagaatcaagcctatgttaa60cttccctcaaagcctgagattttgctttcccattaaatgcaggtagttgttcttcttgca120<210>401<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>401gcactagtcactggccataatttaaatcttgttatcttcttgccaccatgaaccctgtat60gctgtaggctgaaaacgttaaaagaaacacacgctctcacacacacacaaacacacgcg119<210>402<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>402cacacacacacacacacacagagctgactttcaaaatctactccagcccaaatgtttcaa60ttgttcctcacccctggacatactttgcccccatctggaattaaaggatataagtttgta120<210>403<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>403gtaatgaagcattagcagcattttatatgtgtccagctgatataggaatagccttagcaa60tgtatgtttggccaccaaagttccccactttgactgagccaatatatgccttctgcctgc120<210>404<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>404tgcatctttttaatgaccatacttgtcctgcctccagatagatgttttaaaacgaataac60aaaaataggggaaaggtgaaagttctttctaccgaaatctaataaagaaaagtcattttc120<210>405<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>405ttcctcatttccacctctcttttctcaaagtcaaagttgtccatctagattttcagaggc60actccttaggccctaaaacattgccactgggtctcagcccagttagtcctctgcagtttc120<210>406<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>406ttcttcactcccaaccccagtatcttcaaacagctcacaccctgctgtgctcagatcaat60actcagttgtctaagttgcctcgagactaaaggcaacagtgctgaaacatctcctggact120<210>407<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>407actcaccttgaagttctcaggatccacatgcagcttgtcacagtgcagttcactcagctg60ggcaaaggtgcccttgagatcatccaggtgctttatggcatctcccaaggaagtcagcac120<210>408<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>408caccttcttgccatgtgccttgactttggggttgcccatgatggcagaggcagaggacag60gttgccaaagctgtcaaagaacctctgggtccatgggtagacaaccaggagcctgtgaga120<210>409<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>409agattgacaagaacagtttgacagtcagaaggtgccacaaatcctgagaagcgacctgga60cttttgccaggcacagggtccttccttccctcccttgtcctggtcaccagagcctacctt120<210>410<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>410cttcccagggtttctcctccagcatcttccacattcaccttgccccacaggcttgtgata60gtagccttgtcctcctctgtgaaatgacccatggcgtctggactaggagcttattgataa120<210>411<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>411taacctcagacgttccagaagcgagtgtgtggaactgctgaagggtgcttccttttattc60ttcatccctagccagccgccggcccctggcctcactggatactctaagactattggtcaa120<210>412<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>412caagtttgccttgtcaaggctattggtcaaggcaaggctggccaacccatgggtggagtt60tagccagggaccgtttcagacagatatttgcattgagatagtgtggggaaggggccccca120<210>413<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>413ccaagaggatactgctgcttaattttttttatagcctttgccttgttccgattcagtcat60tccaatttttctctaatttattcttccctttagctagttttcttctcccaccatagaaga120<210>414<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>414agataccaggacttcttttgtcagccgtttttcaccttcttgtctgtagctccagtgagg60cctgtagtttaaagttaaagcatgtaccaatttttgaaaagttcagggattgtgaaatgt120<210>415<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>415tgtgttttaggcataggtccaggatttttgatgggacacgtcttagtctcatttagtaag60cattggtttccaaataagaagtgctatacttatctttgaatatactctctgtggttttag120<210>416<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>416taggccattatctcttaagttctcattagtgtagtgaaaaatcctataaagcaacagttt60cagtgcaggaatagattaatgttatgtaatataatataagactgaatccttacttcaata120<210>417<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>417atatctacttatccgtacctatttgaaataaatcacgcctgtttcatctcagcaaaagta60ttttttttatattcaggtatgtatgtaggcacccgatgatgtgtatttatcactggataa120<210>418<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>418taagtgtatgtgctggctgatgacccagggttttggtgtagctcttctatgctcggtaaa60gatgatggtagaatgctctttaccagatactatggattagaattaattatcttgtataaa120<210>419<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>419aaatgctaggttcacttcttagggaatcttattctaagacataagacatgtatttgcatg60gaaaacaactcttaagaggcagggactgttttattgactaatagtccacacactgtgaca120<210>420<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>420acagctgggatgtcactgtagtttagacatctttatctgtaactcagtgctgtttctgac60atattggccacttaacatggcaggaagtattcatgctgtttttttctttattttttcttt120<210>421<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>421ttggttttgcttttgttttttctctgaactcgatccatgaccttggtagattatgacgtc60agaaactctggaaatctggcttattggaggagagctctaccttcccctaacctatcaggt120<210>422<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>422aaactctggaaatctggcttattggaggagagctctaccttcccctaacctatcaggttg60ataggaattataataatattggtggaatcctttcagacttcataatcctgtgtaaggctt120<210>423<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>423aggaattataataatattggtggaatcctttcagacttcataatcctgtgtaaggcttat60atctgctcaaagtgttaggcggctaaaagaccagaaagatacatgttgacctgcgcaac119<210>424<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>424aataaaagttgaataagaaaggaaagaaaaagatttgtcaacttatcagtatcttccagt60tactcacataataataagtgacttctctcaatctaaggatgggtgagaaagatttttatt120<210>425<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>425tattggtatgctggtacagattatagagactgaggtgaacccaaattagggtctctttaa60gataggggatctgtgagatgggtgtgtatagatctttggccatatctgagagtctggttg120<210>426<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>426gttgggttccatttgtagagcctgacctttaagaatgtgtcagagactggtgtctaagcc60cgctaaggcctaaacaagtgaatcttttgaatctctcttttttttttttgagacagagt119<210>427<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>427gtgagccaccactcccagcctctaaacaagtgaatcttaattgctcctcctcagactaag60gaatatctaggatccctcctgttttcaaacaacttccccatttatccaaaaaccaaggca120<210>428<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>428aaaccaaggcagtgttctaaaagtcatgtataaacccttatttcctcttatgcttttgag60gcaatatcttttaagagtttgttgatttctccttatccataactgtcttattcctcgatt120<210>429<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>429attcctcgatttttcctatatcattgcttctgacattgattaaatcctaactgataaaac60tgtttctttacacaagcaatttcaagtgttttcaagcattctttcccatgtattttcaaa120<210>430<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>430gtattttcaaacatttgttcagcaaatatctgttaaataaatgtcataatttttaaagta60gtgggcatttaagttaaataagtcagagaataaaactttcctctgaagattataatctag120<210>431<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>431ttataatctaggtagaacatacataaaattaataattaagttaaacaacaaaataatttc60agatattattaactaagaatgaaattaaggagaaagtattcgaacagaggcaaaatgaca120<210>432<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>432gcaaaatgacagaaggaatctgccatgggaaggcattgccaaataaagtttagaagctga60aatagtaaattcaaagctctgaagcagaagaaaacaaactcctgctgtgccagagagtta120<210>433<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>433ccagagagttagataaagaaccagtgccgttgatatgtaaagtggagaatagcaggtggt60attgtttcagggaagcataaacctaaggacataaacttgtcctcagtggtagggagtgag120<210>434<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>434tagggagtgagaagccattatagaattttaactctggtaatgacataatctctaagcaac60ctgtactattggctggattactattctaagaatgacctgtttatcacaactgttttgctt120<210>435<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>435ctgttttgcttaaaaagcccttattgcctgtggacaattattagttattctttcaactat60taaaaatcttgtcatgcagatgtgtgtgtgtgtgtgtgtattcattatgaatttgctttc120<210>436<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>436aatttgctttcaattaagttatcttgaattggcaatatctaaatctagatatagctccct60aaggggtaaagagtgtatccactgcccacccctcaacatcacgtccttgattccttgata120<210>437<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>437attccttgatatcaaagggcagtatagttttgggggagaagaaaaagagagagagagaaa60aaaagattgattaaaaatgcatattaccgacaaattagagggtgatggcagatgggagg119<210>438<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>438taaaaatatgtatcaaaaaatgcacattgctcccatttgttgactgactaggtgaaaata60tttagtgccatgaataatccctgtttactctgtttatgggcatattgaaaggttataagg120<210>439<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>439aggctcagagagaccagtattgttgatagcctgcaactacaataattatttgtctctctc60ccatattctggatatatacagccaaattcaaaagtaattcacaggaaaaagtctgatcaa120<210>440<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>440caatgtgagagcactataaaattactaataaagttatatttgccaaaatatggcactcta60acttggaaaatgcaaaggttccttgatatgaaagacacaagacctgaaggtcaaaactcc120<210>441<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>441tccctgaccaatctagcacttcctaaaaagtaaatctgttaatatccctctacccttcac60acatgagagtcaccaggtcagtgcatggtttcctcctgttatcttcaccagtctgggagc120<210>442<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>442agctttcagtcatttatcacctccttcttccttctcatctcccacagtcagtcgaatact60atgtctttctcaccccacctttgtccatccttcaaattccacagactcactgctcctctt120<210>443<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>443cttgggtttgaaccattgtatctgtccccttgaatcatcatccatattttattttatctg60caaacttgaatccattttgtgcacataagcagattactttttcccaaaatcttatttcct120<210>444<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>444cctgagtcacttaacatcctaatgcttatcgtttagtattgcaatagcatagtaaaagct60tgtatttttgtagccaggccctgtactatctggtctttcctagtcctctacgtatgtctt120<210>445<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>445cttactctcccttctacttccagagagccagtttcatgcaagtcacgaagccctagcttg60ctggttttagaatttaagcctttattagtattctatctcccacggaaagtcttcatcaca120<210>446<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>446acactctccaaaaactttcccactcaggtcctaactctaactttattttagtgcatgtta60cattctatcagaagataatgcacaatgatatcatgtgtcttagcttcagctaacccatga120<210>447<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>447tgaaataatggaatccttcatggaaagagcaggctattgttgatacacactcatcttatc60tccaaatcaatttcataaaacatgtgacaagctagctacttcaaaatgtaaataagagta120<210>448<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>448gtaaattaaaatagtaattctagcctatatcttggatatctatgaagttttgttttgttt60tgtttttgtttttaatgaaaagtgacatgtaccacaaatctgctttctcaggtaccacta120<210>449<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>449ctaacagctccttctttccccggtgcagtaaaaactgcctaggagtctctgtccacttaa60ttaaccattttcccaccccgataaagatttttctccatcatatcatcctccttggaatcc120<210>450<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>450tcctggaattctcccataacatccacattaattttacaagcccccatacatttcttaagg60aagctcttggttcttcctatgtttctctccatccctcagcccatgaacactttttccttt120<210>451<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>451ttttaacacaagagtaaaagatggagaagataaaattgcaatttttgattactgaagaaa60atgtactttattaaacagaaggctttctctcaaggccaagcccagtccccatgtgcagaa120<210>452<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>452gaaggagggtgtcagggtcacaggaacacctgcaaactggaagagaactcagtggtactt60atgggccagggcaatggcgacagcagacaccagcttctgccaggcagcctgcacttcagg120<210>453<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>453aggggtgaactccttgccaaagtgagtagccagaataatcaccatcacgttacccaggag60ctgttaggcaaaagacaaaataacacacaggcatgttgagtagaagtttccgaaaacaac120<210>454<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>454aacttgatgaaaaaacaaacaaacaaacaaaaacggctttatacctacattcctagacaa60ccctgacctcaaactgttccaaggtttgtgcccacccaaaaaattcagatgagcttaggt120<210>455<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>455ggttcaattttattctatgagccctacattcaacattctacctacctacaccctcacccc60cttccccattttaccagtattattgggttccctctctccctgtttttctttaagcaattg120<210>456<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>456ttgtctaatttttgtaaatgtagaatgtgagtgctgcaagagttctcagcgggagtttaa60aatccccaacaaattcggaaacaagccttcacttggtcacaatactgatgggaaatttaa120<210>457<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>457taacatattttagaaaatgtgtcttatttttctttgagcaaatcttttattttttttgca60aaaatctctttctaaacctcaattatcatgacccacataaaataaggcatttctatttcc120<210>458<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>458tccttgaaatggactttcatctaccaaaagccaaatttcattcttctttcacaagtctac60aattctataatacaattctctgggataaacacatcaagttctggcaagatttcctgaaaa120<210>459<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>459aaagttaagccaattcaggctgttagtagtcctttactgtcactagttctgaatcatgta60agttttggttatgctcactagaagtctgctgttctaacatcaagctcgacccatgatttc120<210>460<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>460ttctgagatctttgttggtctttccaataagattatgagcttcaattaatgtcaaaatat60aaagccaaaaaatcacatcaccagcacctgaactcaccttgaagttctcaggatccacat120<210>461<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>461catgcagcttgtcacagtgcagctcactcagcttagcaaaggcgggcttgaggttgtcca60tgtttttaatagcatctccaaaggaagtcagcaccttcttgccatgggccttgaccttgg120<210>462<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>462tggggttgcccaggatggcagagggagacgacaggtttccaaagctgtcaaaaaatctct60gggtccaggggtaaacaacgaggagtctatgaaatgacaccatatcagatacaaaattag120<210>463<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>463tagagatgcaaaaaatcttgaggactttcccaatcaacttgctagggtaatattcaccct60tcattcccatgcattgagaaccaatgcttacctgcccaaggcttcacctccagcctcttc120<210>464<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>464ttccacattcatcttgctccacaggctagtgacggcagccttctcctcagcagtaaaatg60caccatgatgccaggcctgagagcttgctagtgattgcagctgtgtcggaagcagatatg120<210>465<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>465atgtgctgctgcctctctgtctggccttttattctttactgccgaagttctggccccctg60ttctccatggtacttaaaagtcattggtcaaggctgacctgtgtccctcaggggtggagt120<210>466<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>466agtcaggtccggagagggtcagcagtgatggatggacactaagtttgtgataatgtgtgc60tggatcctgaggctcttttttgttggctcctcatctatctgcaacacaaatttccatttg120<210>467<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>467ttgtccccttttttaccctcttcatcatcttccaaaatgatatccatctctcccattctc60cttttccaagaaagcctcatataaaggagcaaatctcaaaataggaaaaaaagtttcagc120<210>468<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>468agccaaagcgcatttaacatttgccttaaaggtggtgacagtgacaaaaacagggccaag60gaaaagaaaataaagctgttaaaacagaatctcacccagttctagctctcttaaggagtg120<210>469<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>469gtgcattgtaaacaaaacttctgtaccttagtttctctagggagacaaaaaccgtacata60gttccttctagaaactgaacagaatagcaagtagtccacagtgggactaaagccttaatc120<210>470<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>470atcccaaagtacagtaccttggggtgattccctagagaggacagacagaaaagattacat60ccagtgcttccagagaatcctctctcttttcatttctctatgaccacaggggacattggc120<210>471<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>471ggctactttgtgagtattgcctggggctctcttcttgcttgcctgtctgtcctgcttata60cttctcactgggaagggagctgagaagcctaaaatcctaaaattatttaaagccagaatt120<210>472<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>472atttgtcatcaaacagagaaaaaagtgaatcgatatattaatcaggctaggagtcagggt60atattattcctctagtgtccttttttttttctgtatgtccccattttgatgacttgctag120<210>473<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>473tagctctttacttggtagagctgaaactggaagttgggatttacagtgtattcaattcga60tccatgtgcctgaagaatattgctcatgctatatcacttaatctgcccttataataccat120<210>474<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>474cattgtcattatcctcatattttagaatcaaggaataaattcacagaaattatttaacta60tcaatgtgacagaagtaatgattgggggaataatagaagcagagttccacaaattccagc120<210>475<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>475agcattgttaattctataaaagtcccttacatcaccataatctcattgccccagcccagt60tcctccttctggcttgttctacatccatttattttttcttttttctttttcttttctttc120<210>476<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>476atctgcccacctctgcctccgtctccatccatttctaccatttctttctcctatggctcc60ccttgccccaccagatctaggaatttctgttcctacaatttcctgtatgttcaggcccta120<210>477<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>477caatttcctgtatgttcaggccctagaggttcttcgtctttttcacttagcagtatggct60cctgtctcccaagtcaagtgcctttggggattccatattccaagtttactaagagcgttt120<210>478<211>120<212>DNA<213>人工序列<220><221>modified_base<222>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<210>575<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>575ggagggcctctgcatgggtaactctttcaactagccaggggctggactgtggagaaacca60tttccagatagaagtgaggagattccagcaggaaacacttaagagaggatccctggaagt120<210>576<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>576gaagttcggggcaggaggctccctgtcacatgaaggaaacctgctcagcgtaggctctag60gttcttccctactcttatccaatggggcttctgattttaagccagtcttcacaaagcccc120<210>577<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>577gccccagatttctacatgctggagccctgaatgggcaggaagcattgcggtttccatttc60attcagagctctttcataccctgcttccccatagtttgtctcaacatttctgttgataat120<210>578<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>578ataatctgattcatgcaaccaagaattatgagagagccttcagtcatgcctaggcctgca60tttattgttgtgcatatgatggggtagcagacaagaaaacgttaacagcatagactttct120<210>579<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>579tttctcagagctatatgagtttgggaattaatcaagaccagccttttgctcagggtagaa60atcccctatagggatttattcaatgatgggttaaaagctttctatatggtgaggagctca120<210>580<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>580gctcacagattttccaagcccttgcttttgctagacagcttaatgtttatgaaattctta60cacacagaagaatcttctaatcctgggttacataatataacttgattccctattccagaa120<210>581<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>581cagaagataatattcccatattctgaagcattcatgcatttgttaaataataggcatagt60gacaagtgccagaactctaacagtcaaccagagagccacagttttcaacttcacaaagtt120<210>582<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>582aagttaaccatctaactgaagacagcagcaatcaaaaccaccaccccttctccacatggt60gtagtctttcctgatgtcagggatgttaggctcaggttaggaaagtcagactatcatccc120<210>583<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>583atcccagagcaggacacagacgaataaagtgtaattttttagtcacttaggaaaaacagt60ggaatgcaaagagtaaaaaatgctttctgaatggataacttggcctgggaggcctttgga120<210>584<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>584aataaatgtcagttatttttattattacagttaaagatgaatgggcataaagtacagaac60actagttttcacctgcagcaagaatgattgcagttaaacaaaaaatactagcaaacattt120<210>585<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>585atgtcagttatttttattattacagttaaagatgaatgggcataaagtacagaacactag60ttttcacctgcagcaagaatgattgcagttaaacaaaaaatactagcaaacatttctaga120<210>586<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>586ttaatctctgctctatactgcccaagacttttataaagtcaagggttgagtcactgaaat60gagttattgggatggctgtgtgggaagggtgctaagttctttcctaaaggtatgtgagaa120<210>587<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>587aatacaaaggaaagaagcatcctcctttttacacacgtgaactagtgcatgcaaatctga60cactcagtgggcctgggtgaaggtgagaattttattgctgaatgagagcctctggggaca120<210>588<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>588catcttgccagtcaatgagtctcaggttcaatttccttctcagtcttggagtaacagaag60ctcatgcatttaataaacggaaattttgtattgaaatgagagccattggaaatcatttac120<210>589<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>589gcagtgagccccttttcctctaactgaaagaaggaaaaaaaaatggaacccaaaatattc60tacatagtttccatgtcacagccagggctgggcagtctcctgttatttcttttaaaataa120<210>590<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>590aaatattctacatagtttccatgtcacagccagggctgggcagtctcctgttatttcttt60taaaataaatatatcatttaaatgcataaataagcaaaccctgctcgggaatgggaggga120<210>591<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>591gtgagtcagcctagtagagaggcagggcaagccatctcatagctgctgagtgggagagag60aaaagggctcattgtctataaactcaggtcatggctattcttattctcacactaagaaaa120<210>592<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>592ttattctcacactaagaaaaagaatgagatgtctacatataccctgcgtcccctcttgtg60tactggggtccccaagagctctctaaaagtgatggcaaagtcattgcgctagatgccatc120<210>593<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>593tcattgcgctagatgccatcccatctattataaacctgcatttgtctccacacaccagtc60atggacaataaccctcctcccaggtccacgtgcttgtctttgtataatactcaagtaatt120<210>594<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>594tgtataatactcaagtaatttcggaaaatgtattctttcaatcttgttctgttattcctg60tttcaatggcttagtagaaaaagtacatacttgttttcccataaattgacaatagacaat120<210>595<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>595ataaattgacaatagacaatttcacatcaatgtctatatgggtcgttgtgtttgctgtgt60ttgcaaaaactcacaataactttatattgttactactctaagaaagttacaacatggtga120<210>596<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>596agaaagttacaacatggtgaatacaagagaaagctattacaagtccagaaaataaaagtt60atcatcttgaggcctcagctttctaggaataatatcaatattacaaaattaatctaacaa120<210>597<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>597ttacaaaattaatctaacaattatgaacagcaatgagataatgtgtacaaagtacccaga60cctatgtggtagagcatcaaggaagcgcattgcggagcagttttttgtttgtttgttttt120<210>598<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>598catgagccaccactcctggcttgcagactatttaaatgactaattcctgacactacttga60gggatactagacagtagacaacacatctttaatataccaaatgggtgactgtagggttga120<210>599<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>599gttgagagggagattagaattcaatgttttatgaccaaaaaggcttaaatcaggcacaag60cttaggtcttttcaactgtgaggaccggactgaaagtgtgcagttcaaggccctgtagtt120<210>600<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>600tagttgctgtttaactgttcccaggtggaagtctcttcaaagaaccactggtgcaaaaag60ggaactacctggggataaatatttcctccagaaagggggaaagtgcaagctcccctacca120<210>601<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>601taccaaaagcaccaggcaagtccttgtctattttccctgaagttctcaaagaaatgagac60ccttgtttacctttaagattagagaaggcttgaaaagtttgagctgtgcctttggaggcc120<210>602<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>602aggccaacaaacttttctcctttgttgaccaagttcagctctcctgtatgcttccaaggt60ctgttgcatcaagagtgagaattgaaggtcttagaagctgggatctcagatgtagggaaa120<210>603<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>603ggaaaagaggagatttcctgttcactcactgttaagatatggctgaaattttttgatcta60gtcatctacaaagcatgagttgtgggtcagaaattgtttttcacatcttttgacttcctt120<210>604<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>604tcctttgacatcagaatataacctaggaattgattacttaagtgaaggcaaggtactttg60gtctggacaggaacattttgaacaaggtagggagacagctatgaaggcaagcatttattc120<210>605<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>605tattctatctatcatctatctgtctatctatctatctattctttcatccacttatttata60catttaaacaaaaagtatagagcgtagtataatttgtaagtgctcagggctgtgtgtgta120<210>606<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>606gtgtatggattgtttgaaatgaaactaaagtgggagtataattctactgcccccttaacc60ctgtggtccctacactaccctgcaagactcttagctgcttagcttaattgtgaggctgat120<210>607<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>607ctgatttggggcatagcaccccatcctctctgtctttcaacatcctcataataacttgag60aataattttataaaatatcacaatagggtcatgttcagtagggtgatatataaaattaga120<210>608<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>608ttagacaagccatagtttgagtttacccttttgaataaatatatgacaaaaggcaattta60attatctttatgagtttggaggtatccagtatgaaatttagataatacctgccttctagt120<210>609<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>609atagctagtatataactgagaaataattttatttatattataaaacattctaacaataca60gatgtatataaactaaaaaactgaaagggctcatgcaaccctaccttctcaatatcactt120<210>610<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>610tcttcacttagaaaaaaccagccttagctgtctgctatgaatcctttcaaaatatacttc60tgagaaatgagagagagaaatggggagggtagaaggaaggaagatagggtaagagacagg120<210>611<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>611ggaaggaggtgtggggaaagaaattaaattattcttttctctgtctcttgaaagagctct60ttccattacattgaatcaaaggtaatgttgccatttctggactcttgaaataaagaaaga120<210>612<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>612accgatgtatgaaataattttgaaagtctatggcattttcaaaatgcaaggtgatgtctt60actaactagcctttgctttattattagaaatggggaagtgagtatagacattttatcagg120<210>613<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>613gagatatattaggaaaaagggaaactggagaaactgggaggagtatccagatgtcctgtc60cctgtaaggtgggggcacccaccttcaatcaaaagggctccttaacaacttccttgcttg120<210>614<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>614ggggctccaccatcttggaccattagctccacaggtatcttcttccctctagtggtcata60acagcagcttcagctacctctctaaagagtcctgccagatataggtcaggaaatataatc120<210>615<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>615ccactaataaaaagagaaacattttgactgtagttgtttgttttttgtcattgtgactat60caataacattctcactctttcatcagtaatcactcaggttattctgtgaccaacagactg120<210>616<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>616gtgggaaaaatcagagaaggaggcatcctcatgcttactagcctaaactgaaattgctat60agcagagtgaaccagaaggtttacagatattttccacaaagagtaaaaggattgaagcct120<210>617<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>617ttctccagatcaatgcataggaaataataatggaccataaaacccatattatgacgaaca60acattaggataagtccatatcaatttttaatccagtcataagcacagactacgtgaagca120<210>618<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>618acgtccaagtgaaggcaggagaaatgagaggagcaagaaagaggagccatttgatcaaga60atagcagaaaaaggaaaggcaagtcatattaacaaatgattgtcatgccaacagtacaga120<210>619<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>619ataactctgctaataaaggtagaggcataatacaggtagtagcagatatctacatagtag60ttaaaggacatggccatcagtacagaagattccataaaggagaacctaaagaggaagaat120<210>620<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>620taatttgtcagaagcttaaaagctgaactctgaggcattaaactacaatatccttttgac60tgtggaaagggtggtgaaaggaaagttcaaggacatttgagccaacatagagaggaacat120<210>621<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>621ttggcttggtgagggatatctgtcctgatgttgtccaggatggtgatgatacccatataa60ataacgtagagaaaacaggaggggatagagatctagacaaagaggcatcaaagataggga120<210>622<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>622atgtttgtaaggatgaaatagaacgttttttgcgttagtcaccgtgaggatgaccggtaa60aggcaatgcagaggctaatgcctttgttattttttattatttcattttaaattgacaaat120<210>623<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)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tttggggaccaggctgcacagaacccgtcggaagcag120<210>696<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>696gaagcagggcgatcagccgggagctgcagaggcctggggggcctctagcccagggcagcc60tgggaggggcagctgcctgggcacccgggccccgcgaggaggggctggggcctgctgcgg120<210>697<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>697gctgcggggtcgcagatgtgtcccggtgctcggagagggccgcagggcgcgtgggccgtg60gcgggaggccgcgctgctgggagctcacggcccccgccccccgtcccaggctcttcctca120<210>698<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>698ttcctcagccacccgcagaccaagacctacttcccgcacttcgacctgcacccggggtcc60gcgcagttgcgcgcgcacggctccaaggtggtggccgccgtgggcgacgcggtgaagagc120<210>699<211>114<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>699gaagagcatcgacgacatcggcggcgccctgtccaagctgagcgagctgcacgcctacat60cctgcgcgtggacccggtcaacttcaaggtgcgcggggcgcggtgcgggcgggg114<210>700<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>700cgggggtcgccgggcggggcccgggctaggccccgccccctcactgagccgcccccgccc60ccagctcctgtcccactgcctgctggtcaccctggccgcgcgcttccccgccgacttcac120<210>701<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>701tcacggccgaggcccacgccgcctgggacaagttcctatcggtcgtatcctctgtcctga60ccgagaagtaccgctgagcgccgcctccgggacccccaggacaggctgcggcccctcccc120<210>702<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>702cccccgtcctggaggttccccagccccacttaccgcgtaatgcgccaataaaccaatgaa60cgaagcagcgtccacctggtctctgttgtccgtgggcggcgggcgcttggggaggcggag120<210>703<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>703ggagcgggaggagggcgccccggctgtctcggggccactgctgggccgcagggatccttg60caccgaccccagggtctctaagaggcagagggatgtgcagctcccggggcgggagcgggg120<210>704<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>704gggggtcactcgggacccaggcgtggtggagaaggggtgcagttaggcctttgcggaggg60gggagcagtgctggcgcccacccgccgcggctctccctgggacctccgtggtcttccttc120<210>705<211>118<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>705cttctttatttctcccgaatgtgtactatttcctgatttcagaacgatcaggacgaagag60gggagggatgggcgtctgcgctcactcattccttcttccattcctcaatgaaacattt118<210>706<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>706gcaaaaatccaagagtttgatcagactgcaggcgcccctcctccactgggcacccctcat60ccagggcagagggaaccagcccggggcgcaagtccaccggggcatctcatttgctaaaga120<210>707<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>707agggcagagggaaccagcccggggcgcaagtccaccggggcatctcatttgctaaagacc60tgaaaacccaggtgtccatcatcaggactaactggaaaaaccaagggtatccgcaccatg120<210>708<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>708aaaacccaggtgtccatcatcaggactaactggaaaaaccaagggtatccgcaccatgga60gagctcgactgaaaaaaaaaaatgaggataattggataatttcttttttttttttttttt120<210>709<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>709gtgagccaccgcgcccgacctaaaatgaggataatttctaataatgaaaataaagaggtt60agaatggtgtgtatacaatggtggaacagaggagaaacacgaatatgtgtgtgcacatat120<210>710<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>710tggtggaacagaggagaaacacgaatatgtgtgtgcacatatatgtgagcttatgcataa60ctatgtatgaggctgcgtgtggacatgtgtgtttgtgcacaaccatgtatgtgcccgcat120<210>711<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>711aaaaaaaaagagagagaaaattgaaaactcctaattgaaaacccccaaattgaaaactaa60cttaaataaatgagccaatgtaagaatgtggtgatataataatcagaaaaaaggattgtt120<210>712<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>712aatcagaaaaaaggattgttccaggtgacctctgaacacagaacctcggctatgaccgaa60agaactccaaagacactctaacactccgtggtttattgttcctcataacatatataaaat120<210>713<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>713cctcataacatatataaaataatttcataagcttttattttgaaacatattcagattatg60aagaaataaaaacaccctgcaagaataagacaaagatggagaaggaaggatgactgctg119<210>714<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>714ttaacgtggtgacatttgagggagtggcaatactagggaaggggcttcaggggagtggcc60aggagctagggatagagggagggaggacaggaggccttgtctgtcttttcctccatatgt120<210>715<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>715actagggaaggggcttcaggggagtggccaggagctagggatagagggagggaggacagg60aggccttgtctgtcttttcctccatatgtaagtttcaggagtgagtggggggtgtcgagg120<210>716<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>716catgttgtagacaggatgggtgctgagctgccacacccacattattagaaaataacagca60caggcttggggtggaggcgggacacaagactagccagaaggagaaagaaaggtgaaaagc120<210>717<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>717aaagctgttggtgcaaggaagctcttggtatttccaatggcttgggcacaggctgtgagg60gtgcctgggacggcttgtggggcacaggctgcaagaggtgcccaggacggcttgtggggc120<210>718<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>718ggggcacaggttgtgagaggtgccctggacggcttgtggggcacaggctgtgagaggtgc60ccaggacggcttgtggggcacaggctgtgagggtgcccgggacggcttgtggggcacagg120<210>719<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>719acaggttgtgagaggtgcccgggacggcttgtggggcacaggtttcagaggtgcccggga60cggcttgtggggcacaggttgtgagaggtgcccgggacggcttgtgggacacaggttgtg120<210>720<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>720ttgtgagaggtgcctgggacggcttgtggggcacaggctgtgagggtgcctgggacggct60tgtggggcacaggttgtgagaggtgcccgggtcggcttgtggggcacaggttgtgagagg120<210>721<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>721agaggtgcccgggacggcttgtggggcacaggttgtgagacgtgcccgggacggcttgtg60gggcacaggctgtgagggtgcccgggtcggcttgtggggcacaggctgcaagaggtgccc120<210>722<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>722tgcccgggacggcttgtggggcacaggctgtgagggtgcccgggacggcttgtggggcac60aggctgtgagggtgcccgggacagctcgtggggcacaggttgtgagaggtgcccgggacg120<210>723<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>723ggacggcttgtggggcacaggctgtgagggtgcctgggacggcttgtggggcacaggttg60tgagaggtgcccgggacggcttgtggggcacaggttgtgaggatgcccgggatggcttgt120<210>724<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>724cttgtggggcacaggttgtgagaggtgcctgggacggcttgtggggcacaggctgtgagg60gtgcccgggacggcttgtggggcacaggctgtgagaggtgcctgggacggcttgtggggc120<210>725<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>725ggggcacaggctgtgaggatgcccgggacggcttgtggggcacaggttgtgaggggtgcc60caggacggcttgtggggcacaggctgcaagaggtgcccaggacggcttgtggggcacagg120<210>726<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>726acaggttgtgagaggtgcccgggacggcttgtggggcacaggctgtgagggagcccggca60cggcttgcagctacagggagaaaagacttggtgctgtgggcctgccttggggctggtggt120<210>727<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>727gtggtacagcccttatctgctgccctcaggatctcccggcccctctcgtccaggcccctg60caaccccatgccccagcctctgaggaccaaaggcgcccctgcttgggaagagggggctca120<210>728<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>728gctcaggggagtcgcctgacccggttccaagccaggctgatttaccgttgctaacatcct60atcgcacgcatccctctgcctcatgcacccaaccccaaggcctggtacactgcaggcccc120<210>729<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>729gccccaaggtcctgtgcgtcctttcaataccctcctcacctgcctcacctgcccccccta60ccctgactctggctggagaccccctccagggagttttcaaaacaaagggtgtcagtctcc120<210>730<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>730tctcctgtgggattccctcacctctgcagcctgcggtctgaaagctgccccatggtgtgt60agtgctaaacttccaacttactccaggccagcggtgacagcccgagggcaggaagggcac120<210>731<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>731ggcacccacactgagcctcaaacagctaattttgcaactgtaagtccatataattgtctt60gaaaagtaatttgtttcaaaaagctaaaaaacgaatactcttgagtctccttctagtaat120<210>732<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>732gtaattccccttctagaggtctatcaccaggaaaagatccaaagcactgatattcttcat60ggagttgtttataatagaaaaaaactagagcttgttcacaaaggggagctctgcaggctg120<210>733<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>733ggctgaagatgttgcacctgtcagcggggatgggggcacgcttgctgacgcagcaacgga60aaagcatcagtgtgtgaagatgcattttctctctttctattattattatttttattttta120<210>734<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>734cagtgatgcgacctcatcacaaccacgagccaccatgtgcggccccatgagcaagccacc60acgcccagcctttttttcccttgttttaaaaaatcctctatttaaaaaagatgtgcatgg120<210>735<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>735accacgagccaccatgtgcggccccatgagcaagccaccacgcccagcctttttttccct60tgttttaaaaaatcctctatttaaaaaagatgtgcatgggccgggcacggtggttcacgc120<210>736<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>736gtagagctggaggagggtctcctccaggctgcgatgagaacatagtgagcagaattgcag60gcctgcatgacctcaccttctgtgaggagtccggcctcccaagacgctttcctgcctagg120<210>737<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>737ggtgcccggctcagagtgtcccctacaaggctactggaggagaaccccagaccgagcctc60attcaggtgagggggctgcacaccggaggtgggagaggtctgtcccttcccaccctgtga120<210>738<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>738ttgcaaactggagctcataaggtgggccagagaagtttcagtgaagtgaggaatggatcg60tccctctgccagggcccatgtgctctaggtcaccctgtcatcacagggacagggaggtca120<210>739<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>739aggtcaaggacagtcactcctgaggccagtccgggctgggctgaccacgtggactctcat60gcccagattggggccccaatctccctgaagctggggctccagctgtgactcaggggtggg120<210>740<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>740ggtgggcagaaggggagacagaagcgataggttcctcagcccccagtcccacctgagggc60ccctttgtcactggatctgataagaaacaccacccctgcagccccctcccctcacctgac120<210>741<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>741cctgaccaatggccacagcctggctgggcccagctccctgtatataaggggaccctgggg60gctgagcactaccaaggccagtcctgagcaggcccaactccagtgcagccgcccaccctg120<210>742<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>742accctgccgccatgtctctgaccaagacttaggggaccatcattgtgtccatgtgggcca60agatctccacgcaggccgacaccatcggcaccgagactctggagaggtgagtgtcagatg120<210>743<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>743cagatgggactgccagagggactgggtgggaggccaggtatgtgagtggggacagtgggg60agcgggcagtggggaggggaccgtggggaggggacagtgagtaggagacagtggggagag120<210>744<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>744ggagaggacagtggagaggggacagtgaggaggggaccatgggaaggggaccgtggagtg60gggacagtgaggaggggaccatagggaggggacagtggggaggggacagtgaggagggga120<210>745<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>745aggggaccgtggggaggggacagtgaggaggggaccgtggggaggagacagtgaggaggg60gaccgtagggaggggacagtgaggaggggaccgtggggaggggacagtgaggaggggacc120<210>746<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>746gggaccgtggggaggggacagtgaggaggggaccgtgggaaggagacagtgaggagggga60ccttggggaggggacagtgaggaggggaccatggggaggggacagtgaggaggggacaat120<210>747<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>747gacaatggagaggggacagtgaggaggggactgtggggagaggacagtgaggaggggacc60atggggagggcacagtggggaggggagagtgaggaagggacagtgaggaggggactgtgg120<210>748<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>748ctgtggggaggggacagtggagacagatagccttccctctcagtgaggagggcagggtaa60ggagggaacgattaggagttgcacaaccatctgggctcgctgagacctgggcaggcacag120<210>749<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>749gcacaggcccaggttctgacaagcagagggtgaaaggtttcgttctaggcctgaagggcc60ttacagggcagccagggcactacagcctctaaagtcccagcatctgggatcagggcactg120<210>750<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>750gcactgtcccagcttcaaattcccagcatctgatcccctgggaggggccagggagctttt60ccttccctggaacgctgctgggaggtcatgagcctgcagaaggggtggcgggcaacccag120<210>751<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>751acccagtctggggctgggagggaggtcctgtggccagaggagacggtggaggggctgggg60gcaccaggcgtgctggaggcggagggcgggagatttggggaccaggctgcacagaacccg120<210>752<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>752aacccgtcggaagcagggcgatcagccgggagctgcagaggcctggggggcctctagccc60agggcagcctgggaggggcagctgcctgggcacccgggccccgcgaggaggggctggggc120<210>753<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>753tggggcctgctgcggggtcgcagatgtgtcccggtgctcggagagggccgcagggcgcgt60gggccgtggcgggaggccgcgctgctgggagctcacggcccccgccccccgtcccaggct120<210>754<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>754caggctcttcctcagccacccgcagaccaagacctacttcccgcacttcgacctgcaccc60ggggtccgcgcagttgcgcgcgcacggctccaaggtggtggccgccgtgggcgacgcggt120<210>755<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>755cgcggtgaagagcatcgacgacatcggcggcgccctgtccaagctgagcgagctgcacgc60ctacatcctgcgcgtggacccggtcaacttcaaggtgcgcggggcgcggtgcgggcgggg120<210>756<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>756ccgcccccagctcctgtcccactgcctgctggtcaccctggccgcgcgcttccccgccga60cttcacggccgaggcccacgccgcctgggccaagttcctatcggtcgtatcctctgtcct120<210>757<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>757ctgaccgagaagtaccgctgagcgccgcctccgggacccccaggacaggctgcggcccct60cccctgcccttcaccctcccacagttcctgccctgactccaataaatggatgaggacgga120<210>758<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>758gagcgatctgggctctgtgttctcagtattggagggaaggaggggagaagctgagtgatg60ggtccgggggcttcgcaggaactcggtcgtccccactgtcgtcgcggcctggggttcact120<210>759<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>759cttggggggcgccttggggaggttctagcccctgagcaccggagctgcggcccgggtgga60gcggagcagtcccgggccggcccgcggcgtctcctggggtccttgagtcggacgggcgtt120<210>760<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>760tttgtgcgtctcccggcttcccatatcgcacaaagattgtcacttcactaagcgtattgg60aagcgtgtcggggctcagggaacttttccacaaagcctgacgtccgaatcccgggactct120<210>761<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>761ctggcagctacgggggtccctgaggccggtccctccccgactcctaagagagtagggggt60ttcctgcccggtgttctctctccggttcctcccatgtgctccctcctggcagagcagtaa120<210>762<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>762aactttacccgaggggagtaaacagatgcccctaaagtctgcagtaaaggtgcccacgcg60caacggcgtgggtcaatgccagaaaccctgggatcccggaggtcgaggcctccacacaga120<210>763<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>763gacgggaacccgggctggttacgttccccggcgcaggccgagggtccccgcgttcccgcc60gcgctcgggccgataaggacgggcggggtgcccggaggctctataaggaggccagggcgg120<210>764<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>764ggcgggcgcggcccccagagcacgtcaggcggcgccatgctcagcgcccaggagcgcgcc60caaatcgcgcaggtctgggacctgattgcgggccacgaggcgcaattcggggcggagctg120<210>765<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>765tgctgctcaggtcggtagaggcggggtctccgggagctcagggaggtggagatgagggtt60ttgggcgcgtgggccgccaacgccatccaaggtccttcgggtgcggatccccgggctctg120<210>766<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>766tgggcggtgtgggcgctagtgaagccccacgcagccgccctcctccccggtcactgacct60ggtcctgcaggctcttcacggtgtaccccagcaccaaggtctacttcccgcacctgagcg120<210>767<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>767cgcctgccaggacgcgacgcagctgctgagccacgggcagcgcatgctggcggctgtggg60cgcggcggtgcagcacgtggacaacctgcgcgccgcgctgagcccgctggcggacctgca120<210>768<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>768cacgcgctcgtgctgcgcgtggacccagccaactttccggtgaggcctttccggccgggg60caatggtgcagcgcgcagccggggtgggggggctctgggggtccctagcggggcagaccc120<210>769<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>769cccgtctcaccggccccttctcctgcagctgctaatccagtgtttccacgtcgtgctggc60ctcccacctgcaggacgagttcaccgtgcaaatgcaagcggcgtgggacaagttcctgac120<210>770<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>770actggtgtggccgtggtgctgaccgaaaaataccgctgagccctgtgctgcgcaggcctt60ggtctgtgcctgtcaataaacagaggcccgaaccatctgcccctgcctgtgtggtctttg120<210>771<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>771tggggagctagcaaagcgaggtcactattgttggccagtgaagctcagggacctaaaagg60agcctcctagaactctcaaatgcgccccacccccggaggtttgtcctcccatggcgagga120<210>772<211>112<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>772gagtgcgatggggcagagggagcactgtgatgtggcgggggtagggagggtggccttcga60cttcaacccttgaatcgggcttccaaccatactgttcgcaaagcacttcccc112<210>773<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>773cagaaactgaggtcccagagccaaatgtgcaacctaattcgttggcccagagcagagggc60tccgcagacctgttcctttccccttccttcccccatggacacttcctcagtggcaaacct120<210>774<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>774tcagtggcaaacctgcgctagcctggttagccctccctgtgaccctgcagccctggggat60gaggtcgggaggaagtcctcagtggccacaatttggcagacagagcaggtttagtcttcc120<210>775<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>775aggtttagtcttccagcctgctcaatgacaagctgtgcgaccctgggcgtgtcccagagc60tctcaggcctttacctatcgaatagaaaaacaacgtccaactcacgagatttttgaaata120<210>776<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>776agatttttgaaataatttttgaaatcataacacagggtgggtgcctgcagggtcgttgcc60accccacccctccacccagccccagctgccgtgtctcaatctctgcaggtgcccaggcca120<210>777<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>777aggtgcccaggccaaggcactcccttccccaggttccctcttctccctccccaggactgg60gaagggaatcttagggctccaccccaggcttttcagacaaagaataggggctgaggaaag120<210>778<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>778ggggctgaggaaagagtgggaccttggaggtctccaaaccctgaatagggttggctctgg60gttggccatcctgggtctgtgtggggagcactggaccaggcctggcacccaggtctgacc120<210>779<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>779acccaggtctgacctggcagtcagcaacgaggtctgaagagagctgctggaagtggagcc60ctgactgtgagtcggccaaactccccccagcagtcagtgccagtgacctgttgccctgca120<210>780<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>780cctgttgccctgcactgcctgggaccccagcccggtagtttggagaacttggccccacgt60tatctacatcccccaactgtttttttgtttttgggggttttttttttttttgctttgttt120<210>781<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>781gtgagccaccacacccagcccccgcaactgtttacatggataattaacagctttttgtcc60caggcagagtttggtgtgaaagcagcttatgtttcactttggaaaaactgtgctcttctc120<210>782<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>782cttctccccatccaggaagctgcctgggtctgggccatatgtggataccttatgggtata60agctgctcaggaccctgtgtggaagctcaggacaatgccagcgggaaggctaccatgtgg120<210>783<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>783atgtggagagctggtctctgtttgggcaggactaagagacgcagggcagccttgggcaac60ctgtctactctcactcactcctcctcccctttcctgtgccaggcacctcctggcaacttg120<210>784<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>784aacttgccagccaatgaccctgcatcccaggcataagagctcctactctcccccaccttt60cacttttgagcttacacagactcagaaataagctgccgtggtgctgtctcctgaggacaa120<210>785<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>785ggacaaggctaacaccaaggcggtctgggagaaagttggcaaccacactgctggctatgc60cacggaggccctggagaggcaagaaccctcctctccctgctcacaccttgggtccaacgc120<210>786<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>786caacgcccactccagggctccactggccacccctaactattcttaccctggacccagccc60ccagcccctcactctttgcttccccctgaagcatgttcctgaccttcctctcacttggcc120<210>787<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>787ttggccctgagttatggctcagcccagatcaagaaacaatgcaagtaggtggccgacacg60ctgaccaatgccgtggtccacttagatgacatgcccaatgatgtgtctgagctgaggaag120<210>788<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>788aggaagctgcatgtccacgagctgtgggtggacccaggcaacatcagggagagctttggg60ctgggaggaatctagggtgtgggggcagctggccttcctcataggacagaccctcccacg120<210>789<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>789cccacgcgttcagggaggtggagcacaggtggcagtagtatctgcatcccctgactctct60ctccacagttcctgggtaaatgcctgctggtgacctaggcctgccacacccttcccagtt120<210>790<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>790ccagtttacccatgtggtgcctccatggacaaattatttgcttttgtgagtgctgtgttg60acctaaaaacaccattaagctagagcattggtggtcatgccccctgcctgctgggcctcc120<210>791<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>791gcctcccaccaggccctcctcccctccctgccccagcacttcctgatctttgaatgaagt60ccgagtaggcagcagcctgtgtgtgcctgggttctctctgtcccggaatgtgccaacagt120<210>792<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>792aacagtggaggtgtttacctgtc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ggggcgggggtgcgggctgactttctccctcgc120<210>841<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>841gctagggacgctccggcgcccgaaaggaaagggtggcgctgcgctccggggtgcacgagc60cgacagcgcccgaccccaacgggccggccccgccagcgccgctaccgccctgcccccggg120<210>842<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>842ggcgagcgggatgggcgggagtggagtggcgggtggagggtggagacgtcctggcccccg60ccccgcgtgcacccccaggggaggccgagcccgccgcccggccccgcgcaggccccgccc120<210>843<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>843ccgggactcccctgcggtccaggccgcgccccgggctccgcgccagccaatgagcgccgc60ccggccgggcgtgcccccgcgccccaagcataaaccctggcgcgctcgcggcccggcact120<210>844<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>844ctcttctggtccccacagactcagagagaacccaccatggtgctgtctcctgccgacaag60accaacgtcaaggccgcctggggtaaggtcggcgcgcacgctggcgagtatggtgcggag120<210>845<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>845aggccctggagaggtgaggctccctcccctgctccgacccgggctcctcgcccgcccgga60cccacaggccaccctcaaccgtcctggccccggacccaaaccccacccctcactctgctt120<210>846<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>846ttctccccgcaggatgttcctgtccttccccaccaccaagacctacttcccgcacttcga60cctgagccacggctctgcccaggttaagggccacggcaagaaggtggccgacgcgctgac120<210>847<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>847accaacgccgtggcgcacgtggacgacatgcccaacgcgctgtccgccctgagcgacctg60cacgcgcacaagcttcgggtggacccggtcaacttcaaggtgagcggcgggccgggagcg120<210>848<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>848cgatctgggtcgaggggcgagatggcgccttcctcgcagggcagaggatcacgcgggttg60cgggaggtgtagcgcaggcggcggctgcgggcctgggccctcggccccactgaccctctt120<210>849<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>849ttctctgcacagctcctaagccactgcctgctggtgaccctggccgcccacctccccgcc60gagttcacccctgcggtgcacgcctccctggacaagttcctggcttctgtgagcaccgtg120<210>850<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>850tgctgacctccaaataccgttaagctggagcctcggtggccatgcttcttgccccttggg60cctccccccagcccctcctccccttcctgcacccgtacccccgtggtctttgaataaagt120<210>851<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>851gtctgagtgggcggcagcctgtgtgtgcctgagttttttccctcagcaaacgtgccaggc60atgggcgtggacagcagctgggacacacatggctagaacctctctgcagctggatagggt120<210>852<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>852gtaggaaaaggcaggggcgggaggaggggatggaggagggaaagtggagccaccgcgaag60tccagctggaaaaacgctggaccctagagtgctttgaggatgcatttgctctttcccgag120<210>853<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>853agttttattcccagacttttcagattcaatgcaggtttgctgaaataatgaatttatcca60tctttacgtttctgggcactcttgtgccaagaactggctggctttctgcctgggacgtca120<210>854<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>854cactggtttcccagaggtcctcccacatatgggtggtgggtaggtcagagaagtcccact60ccagcatggctgcattgatcccccatcgttcccactagtctccgtaaaacctcccagata120<210>855<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>855tacaggcacagtctagatgaaatcaggggtgcggggtgcaactgcaggccccaggcaatt60caataggggctctactttcacccccaggtcaccccagaatgctcacacaccagacactga120<210>856<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>856gacgccctggggctgtcaagatcaggcgtttgtctctgggcccagctcagggcccagctc60agcacccactcagctcccctgaggctggggagcctgtcccattgcgactggagaggagag120<210>857<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>857agcggggccacagaggcctggctagaaggtcccttctccctggtgtgtgttttctctctg60ctgagcaggcttgcagtgcctggggtatcagagggagggttcccggagctggtagccata120<210>858<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>858taaagccctggccctcaactgataggaatatcttttattccctgagcccatgaatcaccc60ttggtaaacacctatggcaggccctctgcctgcgtttgtgatgtccttcccgcagcctgt120<210>859<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>859gtgggtacagtatcaactgtcaggaagacggtgtcttcgttatttcatcaggaagaatgg60aggtctgacctaaaggtagaaatatgtcaaatgtacagcagagggctggttggagtgcag120<210>860<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>860ttttatcaccttttttaaaacaaaaaagatataaggggtacagcagagtgagtgctgcat60atgcatttactattattcttgggttacatcccaggtactcaataaatgttcactgccctg120<210>861<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>861ctgccctgaagaaacacctgctacgagtcaggcacctcacagttgttatccgtttaattc60tcacaatctgagaagaaactgtcaccctcattttatataataaatgagaaaacagactcg120<210>862<211>119<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>862cagactcgggcaagtgtcacaatagaatcaagaggcagaataaactgacttccaatgcca60aatccatgccgaaattcagtgctataataatgtacatggccgggcgcggtggttcacgc119<210>863<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>863tttgtgtttttagtagagactaaataccatatagtgaacacctaagacggggggccttgg60atccagggcgattcagagggccccggtcggagctgtcggagattgagcgcgcgcggtccc120<210>864<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>864cggtcccgggatctccgacgaggccctggacccccgggcggcgaagctgcggcgcggcgc60cccctggaggccgcgggacccctggccggtccgcgcaggcgcagcggggtcgcagggcgc120<210>865<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>865agggcgcggcgggttccagcgcggggatggcgctgtccgcggaggaccgggcgctggtgc60gcgccctgtggaagaagctgggcagcaacgtcggcgtctacacgacagaggccctggaaa120<210>866<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>866ctggaaaggtgcggcaggctgggcgcccccgcccccaggggccctccctccccaagcccc60ccggacgcgcctcacccacgttcctctcgcaggaccttcctggctttccccgccacgaag120<210>867<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>867cacgaagacctacttctcccacctggacctgagccccggctcctcacaagtcagagccca60cggccagaaggtggcggacgcgctgagcctcgccgtggagcgcctggacgacctacccca120<210>868<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>868taccccacgcgctgtccgcgctgagccacctgcacgcgtgccagctgcgagtggacccgg60ccagcttccaggtgagcggctgccgtgctgggcccctgtccccgggagggccccggcggg120<210>869<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>869cggcggggtgggtgcggggggcgtgcggggcgggtgcaggcgagtgagccttgagcgctc60gccgcagctcctgggccactgcctgctggtaaccctcgcccggcactaccccggagactt120<210>870<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>870gagacttcagccccgcgctgcaggcgtcgctggacaagttcctgagccacgttatctcgg60cgctggtttccgagtaccgctgaactgtgggtgggtggccgcgggatccccaggcgacct120<210>871<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>871gcgaccttccccgtgtttgagtaaagcctctcccaggagcagccttcttgccgtgctctc60tcgaggtcaggacgcgagaggaaggcgccgcccctccccaaggaaaggcgagggcctggg120<210>872<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>872gcctggggcacacccccagtgcccagatccaggcgcgcctctttccacctccagcaggtt60tggggcctcggccatgggggcaccgaactgcgtgcagcctgaccctcccgaatggggtgg120<210>873<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>873ggggtggtaggtgagggccgcgggacgccccgggcggcgggctgcgaggacggccgactc60tgcccatcccgagggcggctggcttcgccctccccactctgcgccgagcacgcggcccgg120<210>874<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>874ggcccggacccaccgcgagaactccgcacctgcagcgtgaacgcacgcgggcggcgttaa60gggcccggggctgactcggagcaggttagggaacagcgccccctcccggcgcgagccggt120<210>875<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>875agccggtacctgcgcagcacccagccgccgcggctgtggcctggaatcggggacctgggg60tgccggggggttgtggtgaaggaggtgggaccagccccagcacctagccacgtagctggc120<210>876<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>876agctggcgaggtggaccaggaaccgacccagacccctgccgtcacccgacatcactacgg60agagtgaagcttttttatatttgtccacataaaaccaatcatggtcattgtagaacttcc120<210>877<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>877aacttccgaaaacaaggcttgctgcaccttcctgtgtatcccaggtccaggaatgggtgc60agcacatccttcagctgccgcttgacacgcggcaaactgtgtcatgtgtaaacaagaaca120<210>878<211>120<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>878aagaacaggacatggctgtcatatccaagagcacatgtgtaacacagacatgccacacac60acacacacacacacacggggtagaggcaggcctcatccacacccctaacatttgatgcgt120<210>879<211>113<212>DNA<213>人工序列<220><221>modified_base<222>(1)<223>生物素修饰<400>879gatgcgtagctgttccagtcttctaggcacatgtagagatgcttttcctcagaaatggta60ttctcaaggtgacactgaggaaaagtggacaggccgggcgcggtggctcacgc113当前第1页1 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